Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing

被引：86
作者：
Kamminga, Jody [1 ,2 ]
Kumfor, Fiona [1 ,3 ,4 ]
Burrell, James R. [1 ,3 ,4 ]
Piguet, Olivier [1 ,3 ,4 ]
Hodges, John R. [1 ,3 ,4 ]
Irish, Muireann [1 ,2 ,4 ]
机构：
[1] Neurosci Res Australia, Sydney, NSW 2031, Australia
[2] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia
[3] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
[4] Australian Res Council Ctr Excellence Cognit & It, Sydney, NSW, Australia
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2015年 / 86卷 / 10期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
GENDER-DIFFERENCES; SOCIAL COGNITION; RECOGNITION; IMPAIRMENTS; SUBTYPES; APHASIA; DISEASE; PROFILE;
D O I：
10.1136/jnnp-2014-309120
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose Right-lateralised semantic dementia (right SD) and behavioural-variant frontotemporal dementia (bvFTD) appear clinically similar, despite different patterns of underlying brain changes. This study aimed to elucidate distinguishing clinical and cognitive features in right SD versus bvFTD, emphasising emotion processing and its associated neural correlates. Methods 12 patients with right SD and 19 patients with bvFTD were recruited. Clinical features were documented. All patients were assessed on standardised neuropsychological tests and a facial emotion processing battery. Performance was compared to 20 age-matched and education-matched controls. Grey matter intensity was related to emotion processing performance using whole-brain voxel-based morphometry analysis. Results Patients with right SD exhibited disproportionate language dysfunction, prosopagnosia and a suggestion of increased obsessive personality/behavioural changes versus patients with bvFTD. In contrast, patients with bvFTD demonstrated pronounced deficits in attention/working memory, increased apathy and greater executive dysfunction, compared to patients with right SD. Decreased empathy, disinhibition and diet changes were common to both dementia subtypes. Emotion processing deficits were present in both FTD syndromes but were associated with divergent patterns of brain atrophy. In right SD, emotion processing dysfunction was associated with predominantly right medial and lateral temporal integrity, compared to mainly left temporal, inferior frontal and orbitofrontal and right frontal gyrus integrity in bvFTD. Conclusions This study demonstrates comparable deficits in facial emotion processing in right SD and bvFTD, in keeping with their similar clinical profiles. These deficits are attributable to divergent neural substrates in each patient group, namely, right lateralised regions in right SD, versus predominantly left lateralised regions in bvFTD.
引用
收藏
页码：1082 / 1088
页数：7
相关论文
共 44 条
[1]  
Andersson JLR., 2010, FMRIB Technical Report TR07JA2
[2]  
[Anonymous], 2006, Doors and people: a test of visual and verbal recall and recognition
[3]   The clinical profile of right temporal lobe atrophy [J].
Chan, Dennis ;
Anderson, Valerie ;
Pijnenburg, Yolande ;
Whitwell, Jennifer ;
Barnes, Jo ;
Scahill, Rachael ;
Stevens, John M. ;
Barkhof, Frederik ;
Scheltens, Philip ;
Rossor, Martin N. ;
Fox, Nick C. .
BRAIN, 2009, 132 :1287-1298
[4]  
Chare L, 2004, J NEUROL NEUROSUR PS, V85, P865
[5]   Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia [J].
Couto, Blas ;
Manes, Facundo ;
Montanes, Patricia ;
Matallana, Diana ;
Reyes, Pablo ;
Velasquez, Marcela ;
Yoris, Adrian ;
Baez, Sandra ;
Ibanez, Agustin .
FRONTIERS IN HUMAN NEUROSCIENCE, 2013, 7
[6]   Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia [J].
Douaud, Gwenaelle ;
Smith, Stephen ;
Jenkinson, Mark ;
Behrens, Timothy ;
Johansen-Berg, Heidi ;
Vickers, John ;
James, Susan ;
Voets, Natalie ;
Watkins, Kate ;
Matthews, Paul M. ;
James, Anthony .
BRAIN, 2007, 130 :2375-2386
[7]  
Ekman P., 1976, Pictures of facial affect
[8]   Slowly progressive defect in recognition of familiar people in a patient with right anterior temporal atrophy [J].
Gainotti, G ;
Barbier, A ;
Marra, C .
BRAIN, 2003, 126 :792-803
[9]   A voxel-based morphometric study of ageing in 465 normal adult human brains [J].
Good, CD ;
Johnsrude, IS ;
Ashburner, J ;
Henson, RNA ;
Friston, KJ ;
Frackowiak, RSJ .
NEUROIMAGE, 2001, 14 (01) :21-36
[10]   Classification of primary progressive aphasia and its variants [J].
Gorno-Tempini, M. L. ;
Hillis, A. E. ;
Weintraub, S. ;
Kertesz, A. ;
Mendez, M. ;
Cappa, S. F. ;
Ogar, J. M. ;
Rohrer, J. D. ;
Black, S. ;
Boeve, B. F. ;
Manes, F. ;
Dronkers, N. F. ;
Vandenberghe, R. ;
Rascovsky, K. ;
Patterson, K. ;
Miller, B. L. ;
Knopman, D. S. ;
Hodges, J. R. ;
Mesulam, M. M. ;
Grossman, M. .
NEUROLOGY, 2011, 76 (11) :1006-1014
12345