Embryo-uterine cross-talk during implantation: the role of Wnt signaling

被引：87

作者：

Chen, Qi ^{[1
,2
]}

Zhang, Ying ^{[1
,2
]}

Lu, Jinhua ^{[1
,2
]}

Wang, Qiang ^{[1
,2
]}

Wang, Shuangjie ^{[1
,2
]}

Cao, Yujing ^{[1
]}

Wang, Haibin ^{[1
]}

Duan, Enkui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

MOLECULAR HUMAN REPRODUCTION | 2009年 / 15卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Wnt signaling; preimplantation embryo development; blastocyst activation; implantation; decidualization; BETA-CATENIN; MOUSE BLASTOCYST; SECRETED PROTEINS; MAPK PATHWAY; RECEPTOR; GENES; DICKKOPF-1; EXPRESSION; PROGESTERONE; TROPHOBLAST;

D O I：

10.1093/molehr/gap009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During mammalian pregnancy, it has been demonstrated that the quality of embryo implantation determines the quality of ongoing pregnancy and fetal development. Recent studies have provided increasing evidence that differential Wnt signaling plays diverse roles in multiple peri-implantation events. This review focuses on recent progress on various aspects of Wnt signaling in preimplantation embryo development, blastocyst activation for implantation and uterine decidualization. Future studies with conditional deletion of Wnt family members are hoped to provide deeper insight on the pathophysiological significance of Wnt proteins on early pregnancy events.

引用

页码：215 / 221

页数：7

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