Macrocyclic NHC complexes of group 10 elements with enlarged aromaticity for biological studies

被引：18

作者：

Bernd, Marco A. ^{[1
,2
]}

Bauer, Elisabeth B. ^{[1
,2
]}

Oberkofler, Jens ^{[1
,2
]}

Bauer, Andreas ^{[1
,3
]}

Reich, Robert M. ^{[1
,2
]}

Kuehn, Fritz E. ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching B Munchen, Germany

[2] Tech Univ Munich, Catalysis Res Ctr, Mol Catalysis, Lichtenbergstr 4, D-85747 Garching B Munchen, Germany

[3] Tech Univ Munich, Chair Organ Chem 1, Catalysis Res Ctr, Lichtenbergstr 4, D-85747 Garching B Munchen, Germany

来源：

DALTON TRANSACTIONS | 2020年 / 49卷 / 40期

关键词：

N-HETEROCYCLIC CARBENE; TRANSITION-METAL-COMPLEXES; ORGANOMETALLIC COMPOUNDS; ANTITUMOR-ACTIVITY; CELLULAR UPTAKE; CANCER-THERAPY; PLATINUM(II); BEARING; ANTIBACTERIAL; CYTOTOXICITY;

D O I：

10.1039/d0dt02598d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two sets of macrocyclic, bio-inspired, non-heme ligands are utilized for the synthesis of Ni-II, Pd-II and Pt-II complexes. The ligands consist of a 16-atom macrocycle, formed by four methylene bridged NHC moieties, with imidazole or benzimidazole as building blocks. The complexes exhibit a square planar coordination geometry and are characterized by NMR, ESI-MS, elemental analysis, SC-XRD and UV/Vis. For complexes incorporating benzimidazole, an evaluation of luminescence properties is performed, and is found that phosphorescence is present for the Pd-II derivative and there is fluorescence for the Pt-II derivative. Stability studies in cell culture medium are performed for subsequent MTT assays. Here, the Ni-II complexes show low to no activity, and Pd-II and Pt-II complexes exhibit remarkable low IC50 values in cisplatin resistant A2780cisR cells.

引用

页码：14106 / 14114

页数：9

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