Molecular Imagine of Abdominal Aortic Aneurysms

被引：31

作者：

Brangsch, Julia ^{[1
]}

Reimann, Carolin ^{[1
]}

Collettini, Federico ^{[1
]}

Buchert, Ralf ^{[1
]}

Botnar, Rene M. ^{[1
,2
,3
,4
,5
]}

Makowski, Marcus R. ^{[1
,2
]}

机构：

[1] Charlie Univ Berlin, Dept Radiol, D-10117 Berlin, Germany

[2] Kings Coll London, Div Imaging Sci & Biomed Engn, London WC2R 2LS, England

[3] Kings Coll London, Med Engn Ctr, Wellcome Trust & Engn, Phys Sci Res Council EPSRC, London SE1 7EH, England

[4] Kings Coll London, Ctr Excellence, British Heart Fdn BHF, London SE5 9NU, England

[5] Kings Coll London, Biomed Res Ctr, Nat Inst Hlth Res NIHR, London SE1 9RT, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 02期

关键词：

MATRIX METALLOPROTEINASES; F-18-FDG UPTAKE; P-SELECTIN; TOMOGRAPHY; INFLAMMATION; WALL; MACROPHAGES; INTEGRIN; MODEL; LOCALIZATION;

D O I：

10.1016/j.molmed.2016.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abdominal aortic aneurysms (AAAs) represent a vascular disease with severe complications. AAAs are currently the overall 10(th) leading cause of death in western countries and their incidence is rising. Although different diagnostic techniques are currently available in clinical practice, including ultrasound (US), magnetic resonance imaging (MRI), and computed tomography (CT), imaging based prediction of life-threatening complications such as aneurysm -rupture remains challenging. Molecular imaging provides a novel diagnostic approach for in vivo visualization of biological processes and pathological alterations at a cellular and molecular level. Its overall aim is to improve our understanding of disease pathogenesis and to facilitate novel diagnostic pathways. This review outlines recent preclinical and clinical developments in molecular MRI, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) for imaging of AAAs.

引用

页码：150 / 164

页数：15

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