In pursuit of carbohydrate-based HIV vaccines, Part 2: The total synthesis of high-mannose-type gp120 fragments-evaluation of strategies directed to maximal convergence

被引：102
作者：
Geng, XD
Dudkin, VY
Mandal, M
Danishefsky, SJ
机构：
[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA
[2] Columbia Univ, Dept Chem, New York, NY 10027 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期
关键词：
antigens; glycoconjugates; glycopeptides; mannosylation; total synthesis;
D O I：
10.1002/anie.200353626
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A layered approach" and a "block approach" were used to assemble the high-mannose glycan of gp120 glycopeptide fragments (e.g. high-mannose-type conjugates gp120316-3351). The glycan was then conjugated with the gp120 peptide segments through direct aspartylation."
引用
收藏
页码：2562 / 2565
页数：4
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