PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF POTASSIUM N-METHYLTRIFLUOROBORATE ISOINDOLIN-1-ONE WITH ARYL AND HETEROARYL CHLORIDES

被引：3
作者：
Nadaf, Rashid N. [1 ]
Seapy, Dave G. [1 ]
机构：
[1] Texas A&M Univ Qatar, Dept Chem, Doha, Qatar
来源：
SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 14期
关键词：
Isoindolinone; methylaminotrifluoroborates; organotrifluoroborates; palladium-catalyzed cross-coupling; potassium N-methyltrifluoroborate isoindolin-1-one; Suzuki-Miyaura cross-coupling; BOC-PROTECTED AMINOMETHYLTRIFLUOROBORATE; DERIVATIVES; INHIBITORS; DISCOVERY; HALIDES; PROFILE;
D O I：
10.1080/00397911.2014.884591
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Potassium N-methyltrifluoroborate isoindolin-1-one was synthesized and used in Suzuki-Miyaura palladium-catalyzed cross-coupling reactions with aryl and heteroaryl chlorides to prepare 29 examples of substituted N-benzyl isoindolin-1-ones. The new approach benefits from mild reaction conditions that tolerate a variety of functional groups. In addition, because of the large number of commercially available aryl and heteroaryl chlorides that can serve as coupling partners, the approach readily provides access to libraries of substituted N-benzyl isoindolin-1-ones.
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页码：2012 / 2020
页数：9
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