Immobilization of boron-rich compound on Fe3O4 nanoparticles: Stability and cytotoxicity

被引：146

作者：

Tishkevich, D., I ^{[1
,2
]}

Korolkov, I., V ^{[3
]}

Kozlovskiy, A. L. ^{[3
,4
]}

Anisovich, M. ^{[5
]}

Vinnik, D. A. ^{[2
]}

Ermekova, A. E. ^{[3
,4
]}

Vorobjova, A., I ^{[6
]}

Shumskaya, E. E. ^{[1
]}

Zubar, T., I ^{[1
,2
]}

Trukhanov, S., V ^{[1
,2
,7
]}

Zdorovets, M., V ^{[3
,4
,8
]}

Trukhanov, A., V ^{[1
,2
,7
]}

机构：

[1] NAS Belarus, SSPA Sci & Pract Mat Res Ctr, Minsk, BELARUS

[2] South Ural State Univ, Chelyabinsk, Russia

[3] Inst Nucl Phys, Alma Ata, Nur Sultan, Kazakhstan

[4] LN Gumilyov Eurasian Natl Univ, Astana, Nur Sultan, Kazakhstan

[5] Republican Unitary Enterprise Sci Pract Ctr Hyg, Minsk, BELARUS

[6] Belarusian State Univ Informat & Radioelect, Minsk, BELARUS

[7] Natl Univ Sci & Technol MISiS, Moscow, Russia

[8] Ural Fed Univ, Ekaterinburg, Russia

来源：

JOURNAL OF ALLOYS AND COMPOUNDS | 2019年 / 797卷

关键词：

Iron oxide; Magnetic nanoparticles; Surface functionalization; Carborane; Boron-neutron capture therapy; IRON-OXIDE NANOPARTICLES; SEPARATION; NANOCOMPOSITE; TOXICITY; DELIVERY;

D O I：

10.1016/j.jallcom.2019.05.075

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Magnetic nanoparticles based on Fe3O4 and their modifications of surface with therapeutic substances are of great interest, especially drug delivery for cancer therapy includes boron-neutron capture therapy. The results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane iron oxide nanoparticles are presented. Energy-dispersive X-ray analysis and Fourier transform infrared spectroscopy with attenuated total reflection (ATR) accessory confirmed change of nanoparticles elemental content after modification and formation of new bond between Fe3O4 and attached molecules. Scanning and transmission electron microscopy showed that Fe3O4 nanoparticles average size is 18.9 nm. Phase parameters were investigated by powder X-ray diffraction, Fe3O4 nanoparticles magnetic behavior was evaluated by Moossbauer spectroscopy. Chemical and colloidal stability was studied using simulated body fluid (phosphate buffer -PBS). Modified nanoparticles have excellent stability in PBS (pH = 7.4), characterized by X-ray diffraction, Moossbauer spectroscopy and dynamic light scattering. Fe3O4 biocompatibility was elucidated in-vitro using cultured mouse embryonic fibroblasts. The obtained results show the increasing of IC50 from 0.110 mg/ml for Fe3O4 to 0.405 mg/ml for Fe3O4-Carborane nanoparticles. Obtained data confirm biocompatibility and stability of synthesized nanoparticles and potential to use them in boron-neutron capture therapy. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：573 / 581

页数：9

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