Cancer Cell Membrane-Camouflaged Micromotor

A type of cancer cell membrane-camouflaged and gold nanoshell-functionalized CaCO3 (CGNCaCO(3)) micromotor and its ability to modulate immune activity are described. The process used to fabricate these micromotors includes the synthesis of CaCO3 particles, the functionalization of the gold nanoshell, and the fusion of cancer cell membrane vesicles onto the gold nanoshell-functionalized CaCO3 (GNCaCO(3)) particles. Due to the benefit of the homotypic binding of the cancer cell membrane, the autonomous movement of CGNCaCO(3) micromotors results in their substantial accumulation on cancer cells. The subcutaneous injection of CGNCaCO(3) micromotors enhances their immune activity by camouflaging cancer cells. Such CGNCaCO(3) micromotors inherit the biological features of natural cancer cells and are able to facilitate a broad range of antigenic and biological processes that common synthetic motors cannot achieve, and thus, these micromotors hold considerable promise for a number of practical biomedical uses.