Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers

被引：66
作者：
Alastruey-Izquierdo, Ana [1 ]
Victoria Castelli, Maria [1 ]
Cuesta, Isabel [1 ]
Monzon, Araceli [1 ]
Cuenca-Estrella, Manuel [1 ]
Luis Rodriguez-Tudela, Juan [1 ]
机构：
[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Micol, Majadahonda 28220, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 04期
关键词：
CUNNINGHAMELLA-BERTHOLLETIAE INFECTION; IN-VITRO SUSCEPTIBILITIES; AMPHOTERICIN-B; INOCULUM PREPARATION; MURINE MODEL; ZYGOMYCOSIS; THERAPY; MUCORMYCOSIS;
D O I：
10.1128/AAC.01467-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The antifungal susceptibility profiles of 77 clinical strains of Mucorales species, identified by internal transcribed spacer sequencing, were analyzed. MICs obtained at 24 and 48 h were compared. Amphotericin B was the most active agent against all isolates, except for Cunninghamella and Apophysomyces isolates. Posaconazole also showed good activity for all species but Cunninghamella bertholletiae. Voriconazole had no activity against any of the fungi tested. Terbinafine showed good activity, except for Rhizopus oryzae, Mucor circinelloides, and Rhizomucor variabilis isolates.
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页码：1686 / 1689
页数：4
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