ANTI-INFLAMMATORY EFFECTS OF ISOKETOCHARBROIC ACID FROM BROWN ALGA, SARGASSUM MICRACANTHUM

被引：0

作者：

Ham, Young Min ^{[1
]}

Yoon, Weon-Jong ^{[1
]}

Lee, Wook Jae ^{[2
]}

Kim, Sang-Cheol ^{[2
]}

Baik, Jong Seok ^{[3
]}

Kim, Jin Hwa ^{[4
]}

Lee, Geun Soo ^{[4
]}

Lee, Nam Ho ^{[3
]}

Hyun, Chang-Gu ^{[3
]}

机构：

[1] JBRI, Jeju 699943, South Korea

[2] Nakdonggang Natl Inst Biol Resources, Chungbuk 742350, South Korea

[3] Jeju Natl Univ, Cosmet Sci Ctr, Dept Chem & Cosmet, Jeju Si, Jeju Do, South Korea

[4] Hanbul Cosmet Co, R&D Ctr, Chungbuk 369830, South Korea

来源：

EXCLI JOURNAL | 2015年 / 14卷

关键词：

brown alga; inflammation; isoketochabrolic acid; Sargassum micracanthum; NF-KAPPA-B; LPS-INDUCED INFLAMMATION; RAW; 264.7; MACROPHAGES; MAPK ACTIVATION; DOWN-REGULATION; ESSENTIAL OIL; CELLS; SUPPRESSION; MEDIATORS; SEAWEEDS;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 mu M. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E-2 (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.

引用

页码：1116 / 1121

页数：6

共 23 条

[1] Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro
Cai, Congyi
Chen, Yicun
Zhong, Shuping
Ji, Bin
Wang, Jinzhi
Bai, Xueting
Shi, Ganggang
[J]. PLOS ONE, 2014, 9 (04):
[2] Isolation, semi-synthesis and bio-evaluation of spatane derivatives from the brown algae Stoechospermum marginatum
Chinnababu, B.
Reddy, S. Purushotham
Rao, P. Sankara
Reddy, V. Loka
Kumar, B. Sudheer
Rao, J. Venkateswara
Prakasham, R. S.
Babu, K. Suresh
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (12) : 2479 - 2483
[3] Anti-inflammatory effects of calcium citrate in RAW 264.7 cells via suppression of NF-κB activation
Choi, Eun-Young
Kim, Hak-Ju
Han, Ji-Sook
[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2015, 39 (01) : 27 - 34
[4] The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro: Down-regulation of NO and iNOS through suppression of NF-κB and MAPK activation
Choi, You Yeon
Kim, Mi Hye
Han, Jae Min
Hong, Jongki
Lee, Tae-Hee
Kim, Sung-Hoon
Yang, Woong Mo
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 19 (02) : 214 - 220
[5] Dutta P, 2016, CURR TOP MED CHEM, V16, P99
[6] Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, Haitao
Callaway, Justin B.
Ting, Jenny P-Y
[J]. NATURE MEDICINE, 2015, 21 (07) : 677 - 687
[7] Ham YM, 2010, INT J PHARMACOL, V6, P147
[8] Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts
Hyun, Tae Kyung
Ko, Yeong-Jong
Kim, Eun-Hye
Chung, Ill-Min
Kim, Ju-Sung
[J]. INDUSTRIAL CROPS AND PRODUCTS, 2015, 74 : 263 - 270
[9] Anti-Inflammatory Activity of Ethanolic Extract of Sargassum micracanthum
Jeong, Da-Hyun
Kim, Koth-Bong-Woo-Ri
Kim, Min-Ji
Kang, Bo-Kyeong
Ahn, Dong-Hyun
[J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2013, 23 (12) : 1691 - 1698
[10] Kim MJ, 2014, EXCLI J, V13, P123

← 1 2 3 →