Synthesis and Evaluation of Antibacterial and Anticancer Activities of Some New Benzoxazole-Piperazine-1,2,3-Triazoles

被引：0
|
作者：
Vidya, K. [1 ]
机构：
[1] JNTUH Coll Engn, Dept Chem, Jagtial, Telangana, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 30卷 / 02期
关键词：
Benzoxazole; 1,2,3-Triazole; Piperazine; Anticancer; Antibacterial activity; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; ANTIMICROBIAL EVALUATION; CANCER; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some new 2-((4-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)piperazin-1-yl)methyl)benzo[d] oxazoles (4a-j) were synthesized through Cu(I) catalyzed [3+2] cycloaddition reaction between 2-((4-(prop-2-yn-1-yl)piperazin-1-yl)methyl)benzo[d]oxazole (3) and several aryl azides. The in vitro anticancer and antibacterial activities evaluation revealed that compounds 4g, 4f, and 4d possess good activities, whereas the remaining compounds are associated with moderate to low activities. [GRAPHICS]
引用
收藏
页码：269 / 274
页数：6
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