Toxicological analysis points to a lower tolerable daily intake of melamine in food

被引：61

作者：

Hsieh, D. P. H. ^{[1
]}

Chiang, C. F. ^{[1
]}

Chiang, P. H. ^{[2
]}

Wen, C. P. ^{[2
]}

机构：

[1] China Med Univ, Taichung 404, Taiwan

[2] Natl Hlth Res Inst, Maoli 350, Taiwan

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2009年 / 55卷 / 01期

关键词：

Food safety; Melamine; Tolerable daily intake (TDI); Health risk assessment;

D O I：

10.1016/j.yrtph.2009.05.004

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Intensified food safety concern over melamine has prompted national authorities to assess its tolerable daily intake (TDI) for protection of general population including young children. TDI is calculated by dividing a no-observed-adverse-effect level (NOAEL) by a safety factor (SF). Based on appropriate choices of values, the US Food and Drug Administration determined two TDI values in the unit of mg per kg body weight per day as first 0.63 and then 0.063, while the World Health Organization, 0.5 and then 0.2, as a result of increasing the SF values in calculation. We used a similar procedure, with judicious selection of pertinent values, to obtain a TDI of 0.0081. Arguments in support of this lower TDI value were provided to alert the international community. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：13 / 16

页数：4