Conserved regulators of cognitive aging: From worms to humans

被引：27

作者：

Arey, Rachel N. ^{[1
]}

Murphy, Coleen T. ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol & LSI Genom, Princeton, NJ 08544 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2017年 / 322卷

关键词：

Aging; Longevity; Cognitive aging; Model systems; Cognitive decline; LONG-TERM-MEMORY; NEMATODE CAENORHABDITIS-ELEGANS; GENOME-WIDE ASSOCIATION; AGE-RELATED DIFFERENCES; INSULIN-RECEPTOR SUBSTRATE; ELEMENT-BINDING PROTEIN; ZEBRAFISH DANIO-RERIO; LIFE-SPAN; CALORIC RESTRICTION; DENDRITIC EXTENT;

D O I：

10.1016/j.bbr.2016.06.035

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：299 / 310

页数：12

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