Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation

被引：14

作者：

Hong, Sungwha ^{[1
]}

Kim, Younghwa ^{[2
]}

Sung, Jeehye ^{[3
]}

Lee, Hana ^{[1
]}

Heo, Huijin ^{[1
]}

Jeong, Heon Sang ^{[1
]}

Lee, Junsoo ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Dept Food Sci & Biotechnol, Cheongju 28644, Chungbuk, South Korea

[2] Kyungsung Univ, Sch Food Biotechnol & Nutr, Busan 48434, South Korea

[3] Andong Natl Univ, Food Sci & Biotechnol, Andong 36729, Gyeongbuk, South Korea

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷

关键词：

LIVER-DISEASE PATHOGENESIS; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; ZIZYPHUS-JUJUBA; INJURY; GLUTATHIONE; EXPRESSION; FLAVONOIDS; CULTIVARS; MECHANISM;

D O I：

10.1155/2020/6684331

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

This study aimed at evaluating the cytoprotective activity of jujube water extract (JWE) against alcohol-induced oxidative stress via the activation of the Nrf2 pathway in HepG2 cells. JWE had various phenolic compounds, and the vanillic acid content was the highest in the extract. To determine the cytoprotective effect of JWE against alcohol-induced damage, hepatocytes were treated with JWE and 3% ethanol. JWE (100 mu g/mL) markedly increased cell viability by approximately 100% in a dose-dependent manner. Moreover, JWE attenuated the production of malondialdehyde, reactive oxygen species, aspartate, and alanine aminotransferase and the depletion of glutathione. Moreover, JWE enhanced the expression of antioxidant defense enzymes including heme oxygenase-1, NADPH quinone oxidoreductase 1, and gamma-glutamate-cysteine ligase catalytic against alcohol-induced oxidative damage in hepatocytes via the activation of Nrf2. Taken together, JWE possesses the protective effect against alcohol-induced oxidative injury in hepatocytes through the upregulation of the Nrf2 signaling pathway. Therefore, jujube fruit might have the potential to improve alcohol-related liver problems.

引用

页数：8

共 44 条

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