Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2

被引：42

作者：

Cornelissen, CN ^{[1
]}

Anderson, JE ^{[1
]}

Sparling, PF ^{[1
]}

机构：

[1] UNIV N CAROLINA, DEPT MICROBIOL & IMMUNOL, SCH MED, CHAPEL HILL, NC 27599 USA

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 02期

关键词：

D O I：

10.1128/IAI.65.2.822-828.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular weight heterogeneities of Tbp1 and Tbp2 among a panel of 45 gonococcal isolates were assessed. The tbpB genes from four of these strains were sequenced to characterize the Thp2 sequence diversity among gonococci. By expressing truncated versions of gonococcal Tbp3, we delimited the extent of Tbp2 necessary for transferrin binding in a Western blot.

引用

页码：822 / 828

页数：7

共 34 条

[1] IMMUNE-RESPONSES IN HUMANS AND ANIMALS TO MENINGOCOCCAL TRANSFERRIN-BINDING PROTEINS - IMPLICATIONS FOR VACCINE DESIGN [J].

ALAALDEEN, DAA ;

STEVENSON, P ;

GRIFFITHS, E ;

GORRINGE, AR ;

IRONS, LI ;

ROBINSON, A ;

HYDE, S ;

BORRIELLO, SP .

INFECTION AND IMMUNITY, 1994, 62 (07) :2984-2990

[2] GONOCOCCAL TRANSFERRIN-BINDING PROTEIN-2 FACILITATES BUT IS NOT ESSENTIAL FOR TRANSFERRIN UTILIZATION [J].

ANDERSON, JE ;

SPARLING, PF ;

CORNELISSEN, CN .

JOURNAL OF BACTERIOLOGY, 1994, 176 (11) :3162-3170

[3]

BRUNHAM R, 1994, COMMUNICATION

[4] GONOCOCCAL TRANSFERRIN-BINDING PROTEIN-1 IS REQUIRED FOR TRANSFERRIN UTILIZATION AND IS HOMOLOGOUS TO TONB-DEPENDENT OUTER-MEMBRANE RECEPTORS [J].

CORNELISSEN, CN ;

BISWAS, GD ;

TSAI, J ;

PARUCHURI, DK ;

THOMPSON, SA ;

SPARLING, PF .

JOURNAL OF BACTERIOLOGY, 1992, 174 (18) :5788-5797

[5] EXPRESSION OF GONOCOCCAL TRANSFERRIN-BINDING PROTEIN-1 CAUSES ESCHERICHIA-COLI TO BIND HUMAN TRANSFERRIN [J].

CORNELISSEN, CN ;

BISWAS, GD ;

SPARLING, PF .

JOURNAL OF BACTERIOLOGY, 1993, 175 (08) :2448-2450

[6] Binding and surface exposure characteristics of the gonococcal transferrin receptor are dependent on both transferrin-binding proteins [J].

Cornelissen, CN ;

Sparling, PF .

JOURNAL OF BACTERIOLOGY, 1996, 178 (05) :1437-1444

[7] TRANSFERRIN-BINDING PROTEINS ISOLATED FROM NEISSERIA-MENINGITIDIS ELICIT PROTECTIVE AND BACTERICIDAL ANTIBODIES IN LABORATORY-ANIMALS [J].

DANVE, B ;

LISSOLO, L ;

MIGNON, M ;

DUMAS, P ;

COLOMBANI, S ;

SCHRYVERS, AB ;

QUENTINMILLET, MJ .

VACCINE, 1993, 11 (12) :1214-1220

[8] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[9] ISOLATION BY STREPTONIGRIN ENRICHMENT AND CHARACTERIZATION OF A TRANSFERRIN-SPECIFIC IRON UPTAKE MUTANT OF NEISSERIA-MENINGITIDIS [J].

DYER, DW ;

MCKENNA, W ;

WOODS, JP ;

SPARLING, PF .

MICROBIAL PATHOGENESIS, 1987, 3 (05) :351-363

[10] EFFECTS OF SERUM CARRIER PROTEINS ON THE GROWTH OF PATHOGENIC NEISSERIAE WITH HEME-BOUND IRON [J].

DYER, DW ;

WEST, EP ;

SPARLING, PF .

INFECTION AND IMMUNITY, 1987, 55 (09) :2171-2175

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