Host Genetic Variants Influencing the Clinical Course of Hepatitis B Virus Infection

被引：54
作者：
Matsuura, Kentaro [1 ,2 ,3 ,4 ]
Isogawa, Masanori [1 ,2 ]
Tanaka, Yasuhito [1 ,2 ]
机构：
[1] Nagoya City Univ, Grad Sch Med Sci, Dept Virol, Nagoya, Aichi 4678601, Japan
[2] Nagoya City Univ, Grad Sch Med Sci, Liver Unit, Nagoya, Aichi 4678601, Japan
[3] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya, Aichi 4678601, Japan
[4] NIH, Infect Dis & Immunogenet Sect, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA
来源：
JOURNAL OF MEDICAL VIROLOGY | 2016年 / 88卷 / 03期
关键词：
HBV; GWAS; fibrosis; HCC; HLA; GENOME-WIDE ASSOCIATION; RECEPTOR-ALPHA POLYMORPHISMS; HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; PROMOTER VARIANT; RISK; SUSCEPTIBILITY; CLEARANCE; EPIDEMIOLOGY; EXPRESSION;
D O I：
10.1002/jmv.24350
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The clinical course of hepatitis B virus (HBV) infection greatly differs in individuals. Various viral, host, and environmental factors influence the natural history of HBV infection. Recent genome-wide association studies identified several host genetic factors influencing the clinical course of HBV infection. Genetic variations in HLA class II loci were significantly associated with susceptibility to persistent HBV infection. Other polymorphisms in or near the genes EHMT2, TCF19, and HLA-C, located near HLA class II loci, and UBE2L3 were also associated with persistent HBV infection. Meanwhile, polymorphisms in KIF1B, GRIK1, and STAT4 were associated with HBV-related hepatocellular carcinoma (HCC). Interestingly, HLA class II genetic variations were strongly associated with not only persistent HBV infection, but also disease progression and HBV-related HCC in chronic hepatitis B. Understanding the various genetic factors associated with the clinical course of HBV infection is essential for personalized treatment and surveillance of disease progression and HCC. (C) 2015 Wiley Periodicals, Inc.
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页码：371 / 379
页数：9
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