Scandium-catalyzed highly selective N2-alkylation of benzotriazoles with cyclohexanones

被引：12

作者：

Tang, Shengbiao ^{[1
]}

Yu, Jianliang ^{[1
]}

Shao, Ying ^{[1
]}

Sun, Jiangtao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Jiangsu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 02期

基金：

中国国家自然科学基金;

关键词：

KETONES; CONDENSATION; HETEROCYCLES; NUCLEOPHILES; TAUTOMERISM; DERIVATIVES; ADDITIONS;

D O I：

10.1039/d0qo01060j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A scandium-catalyzed highly N-2-selective alkylation of benzotriazoles with cyclohexanones has been developed, providing straightforward access to a series of N-2-alkylated benzotriazoles featuring newly formed tetrasubstituted carbon centers in high yields with excellent regioselectivities. The key to the success of this reaction is using Sc(OTf)(3) as the catalyst. Typically, this protocol is also well compatible with 4-aryl-1,2,3-triazoles.

引用

页码：278 / 282

页数：5

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