One-pot concise syntheses of benzimidazo[2,1-a]isoquinolines by a microwave-accelerated tandem process

被引：51

作者：

Okamoto, Noriko ^{[1
,2
]}

Sakurai, Keisuke ^{[1
]}

Ishikura, Minoru ^{[3
]}

Takeda, Kei ^{[2
]}

Yanada, Reiko ^{[1
]}

机构：

[1] Hiroshima Int Univ, Fac Pharmaceut Sci, Hiroshima 7370112, Japan

[2] Hiroshima Univ, Grad Sch Med Sci, Dept Synthet Organ Chem, Minami Ku, Hiroshima 7348553, Japan

[3] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期

关键词：

PALLADIUM-CATALYZED SONOGASHIRA; COPPER-FREE; NUCLEOPHILIC-ADDITION; BIOLOGICAL EVALUATION; COUPLING REACTIONS; ARYL CHLORIDES; AMINE-FREE; ISOQUINOLINES; CYCLIZATION; DESIGN;

D O I：

10.1016/j.tetlet.2009.04.126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct, efficient syntheses of the benzimidazo[2,1-a]isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1,2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4167 / 4169

页数：3

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