Viral manipulation of the host immune response

被引：47

作者：

Christiaansen, Allison ^{[1
]}

Varga, Steven M. ^{[1
,2
,3
]}

Spencer, Juliet V. ^{[4
]}

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA

[3] Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA

[4] Univ San Francisco, Dept Biol, Harney Sci Ctr, San Francisco, CA 94117 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2015年 / 36卷

关键词：

RESPIRATORY SYNCYTIAL VIRUS; PROTEIN-COUPLED RECEPTOR; HUMAN CYTOMEGALOVIRUS-INFECTION; HUMAN INTERLEUKIN-10; CRYSTAL-STRUCTURE; CELLULAR GENE; B-CELLS; IL-10; CHEMOKINE; EXPRESSION;

D O I：

10.1016/j.coi.2015.06.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses are obligate intracellular parasites that require a host for essential machinery to replicate and ultimately be transmitted to new susceptible hosts. At the same time, the immune system has evolved to protect the human body from invasio by viruses and other pathogens. To counter this, viruses have developed an arsenal of strategies to not only avoid immune detection but to actively manipulate host immune responses to create an environment more favorable for infection. Here, we describe recent advances uncovering novel mechanisms by which viruses skew host immune responses through modulation of cytokine and chemokine signaling networks, interference with antigen presentation and T cell responses, and preventing antibody production.

引用

页码：54 / 60

页数：7

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