SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway

被引：15
作者：
Yang, Ning [1 ]
Wang, Yan [1 ]
Hui, Lian [1 ]
Li, Xiaotian [1 ]
Jiang, Xuejun [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Shenyang 110001, Peoples R China
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 11期
关键词：
LSCC; SOX1; SOX2; Apoptosis; Metastasis; Wnt/beta-catenin; METHYLATION STATUS; SIGNALING PATHWAY; TUMOR-SUPPRESSOR; DOWN-REGULATION; CANCER-CELLS; BETA-CATENIN; EXPRESSION; GENE; GROWTH; WNT;
D O I：
10.1007/s13277-015-3389-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sex-determining region Y (SRY)-box protein 1 (SOX 1) has been reported to have the inhibiting effects on various cancer cells; however, the expression and effect of SOX 1 on laryngeal squamous cell carcinoma (LSCC) have not been determined. Therefore, the aim of this study was to assess the anti-proliferation and metastatic effects of SOX 1 and its related mechanisms on LSCC. According to our present study, first, we found that overexpression of SOX 1 could significantly inhibit proliferation and promote apoptosis in Tu212 cells. Additionally, overexpression of SOX 1 suppressed the migration and invasion potential of Tu212 cells via regulating Wnt/beta-catenin pathway. Finally, we demonstrated for the first time that overexpression of SOX 1 could downregulate the expression of SOX 2, and co-expression of SOX 1 and SOX 2 could reverse the anti-tumor effect of SOX 1. In conclusion, our studies suggested that SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt/beta-catenin pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of LSCC.
引用
收藏
页码：8625 / 8635
页数：11
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