Rapidly progressing central nervous system involvement despite of steroid pulse therapy in a case of systemic lupus erythematosus presented as mononeuritis multiplex

被引：0

作者：

Goto, Akiko ^{[1
]}

Kondo, Makoto ^{[1
]}

Minauchi, Koichiro ^{[1
]}

Koizumi, Kazuki ^{[1
]}

Mukai, Masaya ^{[1
]}

机构：

[1] Sapporo City Gen Hosp, Div Rheumatol & Hematol, Dept Med, Chuo Ku, Sapporo, Hokkaido 0608604, Japan

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2008年 / 11卷 / 02期

关键词：

central nervous system; lupus anticoagulant; mononeuritis multiplex; systemic lupus erythematosus;

D O I：

10.1111/j.1756-185X.2008.00355.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 31-year-old-woman with a 6-month history of systemic lupus erythematosus (SLE) was admitted because of severe mononeuritis multiplex. Although she initially responded well with steroid pulse therapy, she developed unconsciousness again 3 weeks later just after a second course of steroid pulse. Laboratory evaluations revealed a high titre of anti-DNA antibody, low complement levels, and positive lupus anticoagulant. She was treated with intravenous cyclophosphamide pulse therapy with immediate response. The clinical course of central nervous system involvement was very Unusual for the response to steroid pulse therapy.

引用

页码：181 / 184

页数：4

共 24 条

[1] CEREBROVASCULAR-DISEASE AND ANTIPHOSPHOLIPID ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS, LUPUS-LIKE DISEASE, AND THE PRIMARY ANTIPHOSPHOLIPID SYNDROME [J].