A Novel Signature of 23 Immunity-Related Gene Pairs Is Prognostic of Cutaneous Melanoma

被引:12
作者
Xue, Ya-Nan [1 ]
Xue, Yi-Nan [2 ]
Wang, Zheng-Cai [1 ]
Mo, Yong-Zhen [3 ]
Wang, Pin-Yan [4 ]
Tan, Wei-Qiang [1 ]
机构
[1] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Plast Surg, Hangzhou, Peoples R China
[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Biol Sci, Jinhua, Zhejiang, Peoples R China
[3] Cent South Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Peoples R China
[4] Cent South Univ, Xiangya Hosp 3, Dept Neurosurg, Changsha, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金
中国国家自然科学基金;
关键词
immune related gene pairs (IRGPs); cutaneous melanoma (CM); immune micro-environment; prognosis; immune check point; EXPRESSION; SURVIVAL; THERAPY; DISEASE; INTERFERON-ALPHA-2B; ACYLTRANSFERASE;
D O I
10.3389/fimmu.2020.576914
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study, we aimed to identify an immune-related signature for predicting prognosis in cutaneous melanoma (CM). Sample data from The Cancer Genome Atlas (TCGA; n = 460) were used to develop a prognostic signature with 23 immune-related gene pairs (23 IRGPs) for CM. Patients were divided into high- and low-risk groups using the TCGA and validation datasets GSE65904 (n = 214), GSE59455 (n = 141), and GSE22153 (n = 79). The ability of the 23-IRGP signature to predict CM was precise, with the stratified high-risk groups showing a poor prognosis, and it had a significant predictive power when used for immune microenvironment and biological analyses. We subsequently established a novel promising prognostic model in CM to determine the association between the immune microenvironment and CM patient results. This approach may be used to discover signatures in other diseases while avoiding the technical biases associated with other platforms.
引用
收藏
页数:18
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共 55 条
[1]   Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts [J].
Al Emran, Abdullah ;
Nsengimana, Jeremie ;
Punnia-Moorthy, Gaya ;
Schmitz, Ulf ;
Gallagher, Stuart J. ;
Newton-Bishop, Julia ;
Tiffen, Jessamy C. ;
Hersey, Peter .
CANCERS, 2020, 12 (08) :1-21
[2]   Knockdown of lecithin retinol acyltransferase increases all-trans retinoic acid levels and restores retinoid sensitivity in malignant melanoma cells [J].
Amann, Philipp M. ;
Czaja, Katharina ;
Bazhin, Alexandr V. ;
Ruehl, Ralph ;
Skazik, Claudia ;
Heise, Ruth ;
Marquardt, Yvonne ;
Eichmueller, Stefan B. ;
Merk, Hans F. ;
Baron, Jens M. .
EXPERIMENTAL DERMATOLOGY, 2014, 23 (11) :832-837
[3]   Vitamin A metabolism in benign and malignant melanocytic skin cells: Importance of lecithin/retinol acyltransferase and RPE65 [J].
Amann, Philipp M. ;
Luo, Chonglin ;
Owen, Robert W. ;
Hofmann, Claudia ;
Freudenberger, Muriel ;
Schadendorf, Dirk ;
Eichmueller, Stefan B. ;
Bazhin, Alexandr V. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (02) :718-728
[4]   The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans [J].
Ardlie, Kristin G. ;
DeLuca, David S. ;
Segre, Ayellet V. ;
Sullivan, Timothy J. ;
Young, Taylor R. ;
Gelfand, Ellen T. ;
Trowbridge, Casandra A. ;
Maller, Julian B. ;
Tukiainen, Taru ;
Lek, Monkol ;
Ward, Lucas D. ;
Kheradpour, Pouya ;
Iriarte, Benjamin ;
Meng, Yan ;
Palmer, Cameron D. ;
Esko, Tonu ;
Winckler, Wendy ;
Hirschhorn, Joel N. ;
Kellis, Manolis ;
MacArthur, Daniel G. ;
Getz, Gad ;
Shabalin, Andrey A. ;
Li, Gen ;
Zhou, Yi-Hui ;
Nobel, Andrew B. ;
Rusyn, Ivan ;
Wright, Fred A. ;
Lappalainen, Tuuli ;
Ferreira, Pedro G. ;
Ongen, Halit ;
Rivas, Manuel A. ;
Battle, Alexis ;
Mostafavi, Sara ;
Monlong, Jean ;
Sammeth, Michael ;
Mele, Marta ;
Reverter, Ferran ;
Goldmann, Jakob M. ;
Koller, Daphne ;
Guigo, Roderic ;
McCarthy, Mark I. ;
Dermitzakis, Emmanouil T. ;
Gamazon, Eric R. ;
Im, Hae Kyung ;
Konkashbaev, Anuar ;
Nicolae, Dan L. ;
Cox, Nancy J. ;
Flutre, Timothee ;
Wen, Xiaoquan ;
Stephens, Matthew .
SCIENCE, 2015, 348 (6235) :648-660
[5]   ImmPort: disseminating data to the public for the future of immunology [J].
Bhattacharya, Sanchita ;
Andorf, Sandra ;
Gomes, Linda ;
Dunn, Patrick ;
Schaefer, Henry ;
Pontius, Joan ;
Berger, Patty ;
Desborough, Vince ;
Smith, Tom ;
Campbell, John ;
Thomson, Elizabeth ;
Monteiro, Ruth ;
Guimaraes, Patricia ;
Walters, Bryan ;
Wiser, Jeff ;
Butte, Atul J. .
IMMUNOLOGIC RESEARCH, 2014, 58 (2-3) :234-239
[6]   AKT1 Activation Promotes Development of Melanoma Metastases [J].
Cho, Joseph H. ;
Robinson, James P. ;
Arave, Rowan A. ;
Burnett, William J. ;
Kircher, David A. ;
Chen, Guo ;
Davies, Michael A. ;
Grossmann, Allie H. ;
VanBrocklin, Matthew W. ;
McMahon, Martin ;
Holmen, Sheri L. .
CELL REPORTS, 2015, 13 (05) :898-905
[7]   Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy [J].
Cirenajwis, Helena ;
Ekedahl, Henrik ;
Lauss, Martin ;
Harbst, Katja ;
Carneiro, Ana ;
Enoksson, Jens ;
Rosengren, Frida ;
Werner-Hartman, Linda ;
Torngren, Therese ;
Kvist, Anders ;
Fredlund, Erik ;
Bendahl, Par-Ola ;
Jirstrom, Karin ;
Lundgren, Lotta ;
Howlin, Jillian ;
Borg, Ake ;
Gruvberger-Saal, Sofia K. ;
Saal, Lao H. ;
Nielsen, Kari ;
Ringner, Markus ;
Tsao, Hensin ;
Olsson, Hakan ;
Ingvar, Christian ;
Staaf, Johan ;
Jonsson, Goran .
ONCOTARGET, 2015, 6 (14) :12297-12309
[8]   Gene Expression Omnibus: NCBI gene expression and hybridization array data repository [J].
Edgar, R ;
Domrachev, M ;
Lash, AE .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :207-210
[9]   Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance [J].
El Hassouni, Btissame ;
Sarkisjan, Dzjemma ;
Vos, J. Chris ;
Giovannetti, Elisa ;
Peters, Godefridus J. .
CURRENT MEDICINAL CHEMISTRY, 2019, 26 (33) :6020-6032
[10]   Statistical predictions with glmnet [J].
Engebretsen, Solveig ;
Bohlin, Jon .
CLINICAL EPIGENETICS, 2019, 11 (01)