Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct and indirect microbicidal activities against such pathogens. The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides. Peptides with antifungal and antiparasitic activities are discussed in less detail, although the broad-spectrum activities of such peptides indicate that they are important host defense molecules. Knowledge regarding the relationship between peptide structure and function as well as their mechanism of action is being applied in the design of antimicrobial peptide variants as potential novel therapeutic agents.
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ABOUDY Y, 1994, INT J PEPT PROT RES, V43, P573
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Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, SpainUniv Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Alberola, J
Rodríguez, A
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机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Rodríguez, A
Francino, O
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机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Francino, O
Roura, X
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机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Roura, X
Rivas, L
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机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Argyris, EG
Acheampong, E
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机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Acheampong, E
Nunnari, G
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机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Nunnari, G
Mukhtar, M
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机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Mukhtar, M
Williams, KJ
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机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Williams, KJ
Pomerantz, RJ
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机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, SpainUniv Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Alberola, J
Rodríguez, A
论文数: 0引用数: 0
h-index: 0
机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Rodríguez, A
Francino, O
论文数: 0引用数: 0
h-index: 0
机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Francino, O
Roura, X
论文数: 0引用数: 0
h-index: 0
机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
Roura, X
Rivas, L
论文数: 0引用数: 0
h-index: 0
机构:Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Argyris, EG
Acheampong, E
论文数: 0引用数: 0
h-index: 0
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Acheampong, E
Nunnari, G
论文数: 0引用数: 0
h-index: 0
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Nunnari, G
Mukhtar, M
论文数: 0引用数: 0
h-index: 0
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Mukhtar, M
Williams, KJ
论文数: 0引用数: 0
h-index: 0
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA
Williams, KJ
Pomerantz, RJ
论文数: 0引用数: 0
h-index: 0
机构:Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Dorrance H Hamilton Labs, Div Infect Dis & Environm Med,Ctr Human Virol & B, Philadelphia, PA 19107 USA