Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion

被引：12
|
作者：
Kim, Eun Kyoung [1 ]
Ha, Jung Min [1 ]
Kim, Young Whan [1 ]
Jin, Seo Yeon [1 ]
Ha, Hong Koo [2 ]
Bae, Sun Sik [1 ]
机构：
[1] Pusan Natl Univ, Sch Med, Dept Pharmacol, MRC Ischem Tissue Regenerat,Med Res Inst, Pusan 609735, South Korea
[2] Pusan Natl Univ, Dept Urol, Sch Med, Pusan 609735, South Korea
来源：
FEBS LETTERS | 2014年 / 588卷 / 17期
关键词：
alpha-Linolenic acid; Lysophosphatidic acid; Migration; Adhesion; Vinculin; Calcium mobilization; SELECTIVE ACTIVATION; RHO; VINCULIN; METASTASIS; CROSSTALK; RECEPTORS; INTEGRINS; SECRETION; MOTILITY; SIGNALS;
D O I：
10.1016/j.febslet.2014.05.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group-containing PUFAs inhibit lysophosphatidic acid (LPA)-induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group-containing PUFAs inhibit LPA-induced calcium mobilization, whereas ethyl ester-group containing PUFAs have no effect. In addition, carboxyl group-containing PUFAs functionally inhibit LPA-dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA-induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group-containing PUFAs may have a functional role in this regulatory mechanism. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2971 / 2977
页数：7
相关论文
共 50 条
  • [41] Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells
    Jung, ID
    Lee, J
    Lee, KB
    Park, CG
    Kim, YK
    Seo, DW
    Park, D
    Lee, HW
    Han, JW
    Lee, HY
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (08): : 1557 - 1565
  • [42] Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells
    Diaz-Aragon, Ricardo
    Ramirez-Ricardo, Javier
    Cortes-Reynosa, Pedro
    Simoni-Nieves, Arturo
    Gomez-Quiroz, Luis-Enrique
    Perez Salazar, Eduardo
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2019, 457 (1-2) : 119 - 132
  • [43] Eicosopentaneoic Acid and Other Free Fatty Acid Receptor Agonists Inhibit Lysophosphatidic Acid- and Epidermal Growth Factor-Induced Proliferation of Human Breast Cancer Cells
    Hopkins, Mandi M.
    Zhang, Zhihong
    Liu, Ze
    Meier, Kathryn E.
    JOURNAL OF CLINICAL MEDICINE, 2016, 5 (02)
  • [44] Phosphorylation of CREB, a cyclic AMP responsive element binding protein, contributes partially to lysophosphatidic acid-induced fibroblast cell proliferation
    Won, Yong-Jun
    Sun, Yuanjie
    Kim, Nam-Ho
    Huh, Sung-Oh
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (03) : 655 - 659
  • [45] Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid
    Volpato, Milene
    Ingram, Nicola
    Perry, Sarah L.
    Spencer, Jade
    Race, Amanda D.
    Marshall, Catriona
    Hutchinson, John M.
    Nicolaou, Anna
    Loadman, Paul M.
    Coletta, P. Louise
    Hull, Mark A.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2021, 87 (02) : 173 - 184
  • [46] The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion
    Anguiano, Maria
    Morales, Xabier
    Castilla, Carlos
    Pena, Alejandro Rodriguez
    Ederra, Cristina
    Martinez, Martin
    Ariz, Mikel
    Esparza, Maider
    Amaveda, Hippolyte
    Mora, Mario
    Movilla, Nieves
    Garcia Aznar, Jose Manuel
    Cortes-Dominguez, Ivan
    Ortiz-de-Solorzano, Carlos
    PLOS ONE, 2020, 15 (01):
  • [47] Lysophosphatidic Acid Stimulates Activation of Focal Adhesion Kinase and Paxillin and Promotes Cell Motility, via LPA1-3, in Human Pancreatic Cancer
    Liao, Yan
    Mu, Ganggang
    Zhang, Lingli
    Zhou, Wei
    Zhang, Jun
    Yu, Honggang
    DIGESTIVE DISEASES AND SCIENCES, 2013, 58 (12) : 3524 - 3533
  • [48] Controversy about the critical role of long-chain polyunsaturated fatty acids, arachidonic acid (ARA) and docosahexaenoic acid (DHA), during infancy
    Campoy, Cristina
    Chisaguano Tonato, Aida Maribel
    de la Garza Puente, Andrea
    Seenz de Pipaon, Miguel
    Verduci, Elvira
    Koletzko, Berthold
    Gonzalez Casanova, Ines
    Larque, Elvira
    Valenzuela, Rodrigo
    Moreno Villares, Jose Manuel
    Gil, Angel
    NUTRICION HOSPITALARIA, 2021, 38 (05) : 1101 - 1112
  • [49] Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays
    Willier, Semjon
    Butt, Elke
    Grunewald, Thomas G. P.
    BIOLOGY OF THE CELL, 2013, 105 (08) : 317 - 333
  • [50] Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
    Kusama, T
    Mukai, M
    Ayaki, M
    Imamura, F
    Tatsuta, M
    Matsumoto, Y
    Nakamura, H
    Inoue, M
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2003, 23 (04) : 1173 - 1178
12345