Colistin Resistance in a Clinical Acinetobacter baumannii Strain Appearing after Colistin Treatment: Effect on Virulence and Bacterial Fitness

被引：75
作者：
Lopez-Rojas, Rafael [1 ,3 ]
McConnell, Michael J. [1 ,3 ]
Enrique Jimenez-Mejias, Manuel [1 ,3 ]
Dominguez-Herrera, Juan [1 ,3 ]
Fernandez-Cuenca, Felipe [2 ,3 ]
Pachon, Jeronimo [1 ,3 ]
机构：
[1] Univ Seville, CSIC, Univ Hosp Virgen del Rocio, Inst Biomed Seville IBiS, Seville, Spain
[2] Univ Hosp Virgen Macarena, Unit Infect Dis & Clin Microbiol, Seville, Spain
[3] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI RD12 0015, Madrid, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 09期
关键词：
PHOSPHOETHANOLAMINE MODIFICATION; IMPAIRED VIRULENCE; LIPOPOLYSACCHARIDE; INFECTIONS; FRANCE; SYSTEM;
D O I：
10.1128/AAC.00543-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The fitness and virulence costs associated with the clinical acquisition of colistin resistance by Acinetobacter baumannii were evaluated. The growth of strain CR17 (colistin resistant) was less than that of strain CS01 (colistin susceptible) when the strains were grown in competition (72-h competition index, 0.008). In a murine sepsis model, CS01 and CR17 reached spleen concentrations when coinfecting of 9.31 and 6.97 log(10) CFU/g, respectively, with an in vivo competition index of 0.016. Moreover, CS01 was more virulent than CR17 with respect to mortality and time to death.
引用
收藏
页码：4587 / 4589
页数：3
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