Radiation-induces increased tumor cell aggressiveness of tumors of the glioblastomas?

被引：3
|
作者：
Falk, Alexander T. [1 ]
Moncharmont, Coralie [2 ,3 ]
Guilbert, Matthieu [4 ]
Guy, Jean-Baptiste [2 ]
Alphonse, Gersende [3 ]
Trone, Jane-Chloe [2 ]
Rivoirard, Romain [2 ]
Gilormini, Marion [3 ]
Toillon, Robert-Alain [4 ]
Rodriguez-Lafrasse, Claire [3 ]
Magne, Nicolas [2 ,3 ]
机构：
[1] Ctr Antoine Lacassagne, Dept Radiotherapie, F-06189 Nice, France
[2] Inst Cancerol Lucien Neuwirth, Dept Radiotherapie, F-42271 St Priest En Jarez, France
[3] Fac Med Lyon Sud, EMR3738, Lab Radiobiol Cellulaire & Mol, F-69921 Oullins, France
[4] Univ Lille 1, IFR 147, Inserm U908, F-59000 Villeneuve Dascq, France
来源：
BULLETIN DU CANCER | 2014年 / 101卷 / 09期
关键词：
glioblastoma; radiotherapy; photons; hadron-therapy; migration; invasion; IONIZING-RADIATION; GLIOMA-CELLS; MATRIX METALLOPROTEINASES; SIGNALING PATHWAY; INDUCED MIGRATION; ION IRRADIATION; GROWTH; TEMOZOLOMIDE; RADIORESISTANCE; RADIOTHERAPY;
D O I：
10.1684/bdc.2014.1946
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines. We realized a review of the literature of photon-enhanced effect on invasion and migration of glioblastoma cells by radiotherapy.
引用
收藏
页码：876 / 880
页数：5
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