A series of 6-and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: Discovery of a potential atypical antipsychotic agent

被引：26

作者：

Belliotti, TR ^{[1
]}

Wustrow, DJ ^{[1
]}

Brink, WA ^{[1
]}

Zoski, KT ^{[1
]}

Shih, YH ^{[1
]}

Whetzel, SZ ^{[1
]}

Georgic, LM ^{[1
]}

Corbin, AE ^{[1
]}

Akunne, HC ^{[1
]}

Heffner, TG ^{[1
]}

Pugsley, TA ^{[1
]}

Wise, LD ^{[1
]}

机构：

[1] Warner Lambert Co, Parke Davis Pharmaceut Res Div, Ann Arbor, MI 48105 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 25期

关键词：

D O I：

10.1021/jm990277d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of a program to develop dopamine D4 antagonists for the treatment of schizophrenia, we discovered a series of 6- and 7-(phenylpiperazinyl)- and -(phenylpiperidinyl)methylbenzoxazinones through mass screening of our compound library. A structure-activity relationship SAR study was carried out involving substituents on the phenyl ring, and several selective D4 antagonists were identified. The 7-substituted benzoxazinones showed more activity in neurochemical and behavioral tests than the 6-substituted series. One of the most potent and selective compounds (26) was found to have potent activity in animal tests predictive of antipsychotic activity in humans after oral administration. This paper describes the SAR of the benzoxazinone series and the preclinical characterization of 26.

引用

页码：5181 / 5187

页数：7

共 36 条

[1] DIFFERENTIAL-EFFECTS OF CLASSICAL AND NEWER ANTIPSYCHOTICS ON THE HYPERMOTILITY INDUCED BY 2 DOSE LEVELS OF D-AMPHETAMINE [J].

ARNT, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 283 (1-3) :55-62

[2] DOPAMINE AND THE PATHO-PHYSIOLOGY OF DYSKINESIAS INDUCED BY ANTIPSYCHOTIC-DRUGS [J].

BALDESSARINI, RJ .

ANNUAL REVIEW OF NEUROSCIENCE, 1980, 3 :23-41

[3] Novel cyclohexyl amides as potent and selective D-3 dopamine receptor ligands [J].

Belliotti, TR ;

Kesten, SR ;

Rubin, JR ;

Wustrow, DJ ;

Georgic, LM ;

Zoski, KT ;

Akunne, HC ;

Wise, LD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (18) :2403-2408

[4] Isoindolinone enantiomers having affinity for the dopamine D4 receptor [J].

Belliotti, TR ;

Brink, WA ;

Kesten, SR ;

Rubin, JR ;

Wustrow, DJ ;

Zoski, KT ;

Whetzel, SZ ;

Corbin, AE ;

Pugsley, TA ;

Heffner, TG ;

Wise, LD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (12) :1499-1502

[5] DOPAMINE - A PROLACTIN-INHIBITING HORMONE [J].

BENJONATHAN, N .

ENDOCRINE REVIEWS, 1985, 6 (04) :564-589

[6] N-(substituted-phenyl) piperazines: Antagonists with high binding and functional selectivity for dopamine D-4 receptors [J].

Boyfield, I ;

Coldwell, MC ;

Hadley, MS ;

Healy, MAM ;

Johns, A ;

Nash, DJ ;

Riley, GJ ;

Scott, EE ;

Smith, SA ;

Stemp, G ;

Wilson, K .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (11) :1227-1232

[7] Design and synthesis of 2-naphthoate esters as selective dopamine D-4 antagonists [J].

Boyfield, I ;

Brown, TH ;

Coldwell, MC ;

Cooper, DG ;

Hadley, MS ;

Hagan, JJ ;

Healy, MA ;

Johns, A ;

King, RJ ;

Middlemiss, DN ;

Nash, DJ ;

Riley, GJ ;

Scott, EE ;

Smith, SA ;

Stemp, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (10) :1946-1948

[8]

BRAFF DL, 1978, PSYCHOPHYSIOLOGY, V14, P339

[9]

Bristow LJ, 1997, J PHARMACOL EXP THER, V283, P1256

[10]

ELLENBROEK BA, 1987, PSYCHOPHARMACOLOGY, V93, P343

← 1 2 3 4 →