Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions

被引:76
作者
Gullapalli, RP
Sheth, BB
机构
[1] Banner Pharmacaps Inc, High Point, NC 27265 USA
[2] Univ Tennessee, Dept Pharmaceut Sci, Memphis, TN 38163 USA
关键词
emulsions; stability; particle size; polarity; hydrocarbons; triglycerides;
D O I
10.1016/S0939-6411(99)00048-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Properties of oil-in-water emulsions containing non-ionic emulsifiers were evaluated in relation to nature of the dispersed phase, emulsifier composition and processing parameters. Particle size of mineral oil (hydrocarbons)-in-water emulsions was independent of the HLB of an optimized emulsifier blend, whereas, the particle size of olive oil (triglycerides)-in-water emulsions was the smallest at the optimum HLB of the emulsifier blend. The non-ionic emulsifiers reduced the particle size of mineral oil emulsions more efficiently than that of olive oil emulsions. Contrary to previously published reports, the nature of the dispersed phase, HLB of the emulsifier blend or the initial particle size of emulsions showed no influence on the final particle stability of the emulsions. This difference was attributed to the optimization of the emulsifier blend and processing parameters in the preparation of emulsions. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:233 / 238
页数:6
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