Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects

被引：31

作者：

Shi, Huan ^{[1
]}

Sun, Meili ^{[2
]}

Liu, Lin ^{[1
]}

Wang, Zhehai ^{[1
]}

机构：

[1] Shandong Canc Hosp & Inst, Dept Oncol, Jinan 250117, Shandong, Peoples R China

[2] Shandong Univ, Jinan Cent Hosp, Dept Oncol, Jinan 250013, Shandong, Peoples R China

来源：

MOLECULAR CANCER | 2014年 / 13卷

基金：

美国国家科学基金会;

关键词：

Adoptive transfer; Chimeric antigen receptor; Gene transfer; T cells; HUMAN T-CELLS; CYTOKINE RELEASE SYNDROME; IN-VIVO PERSISTENCE; ANTITUMOR-ACTIVITY; SIGNALING DOMAIN; PHASE-I; GENETIC-MODIFICATION; TUMOR-LOCALIZATION; ANTI-PD-1; ANTIBODY; CLINICAL-TRIAL;

D O I：

10.1186/1476-4598-13-219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critical issues related to CAR therapy, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules.

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