Anticoagulants for acute lung injury: Barking up the wrong tree

被引：2
作者：
Abraham, Edward [1 ]
机构：
[1] Univ Alabama, Dept Med, Birmingham, AL 35294 USA
来源：
CRITICAL CARE MEDICINE | 2009年 / 37卷 / 06期
关键词：
acute lung injury; sepsis; coagulation; fibrinolysis; neutrophil; urokinase; plasminogen activator inhibitor-1; vitronectin; PLASMINOGEN-ACTIVATOR INHIBITOR-1; INDUCED NEUTROPHIL ACTIVATION; RANDOMIZED CONTROLLED-TRIAL; JNK-MEDIATED PATHWAY; SEVERE SEPSIS; KRINGLE DOMAIN; PROTEIN-C; COAGULATION; FIBRINOLYSIS; VITRONECTIN;
D O I：
10.1097/CCM.0b013e3181a5ea63
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：2100 / 2101
页数：2
相关论文
共 20 条
[1]   Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation [J].
Abraham, E ;
Gyetko, MR ;
Kuhn, K ;
Arcaroli, J ;
Strassheim, D ;
Park, JS ;
Shetty, S ;
Idell, S .
JOURNAL OF IMMUNOLOGY, 2003, 170 (11) :5644-5651
[2]   Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis -: A randomized controlled trial [J].
Abraham, E ;
Reinhart, K ;
Opal, S ;
Demeyer, I ;
Doig, C ;
Rodriguez, AL ;
Beale, R ;
Svoboda, P ;
Laterre, PF ;
Simon, S ;
Light, B ;
Spapen, H ;
Stone, J ;
Seibert, A ;
Peckelsen, C ;
De Deyne, C ;
Postier, R ;
Pettilä, V ;
Sprung, CL ;
Artigas, A ;
Percell, SR ;
Shu, V ;
Zwingelstein, C ;
Tobias, J ;
Poole, L ;
Stolzenbach, JC ;
Creasey, AA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (02) :238-247
[3]   Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death [J].
Abraham, E ;
Laterre, P ;
Garg, R ;
Levy, H ;
Talwar, D ;
Trzaskoma, BL ;
Francois, B ;
Guy, JS ;
Bruckmann, M ;
Rea-Neto, A ;
Rossaint, R ;
Perrotin, D ;
Sablotzki, A ;
Arkins, N ;
Utterback, BG ;
Macias, WL .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) :1332-1341
[4]   Coagulation abnormalities in acute lung injury and sepsis [J].
Abraham, E .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 22 (04) :401-404
[5]   Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator inhibitor-1 through a JNK-mediated pathway [J].
Arndt, PG ;
Young, SK ;
Worthen, GS .
JOURNAL OF IMMUNOLOGY, 2005, 175 (06) :4049-4059
[6]   Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].
Bernard, GR ;
Vincent, JL ;
Laterre, P ;
LaRosa, SP ;
Dhainaut, JF ;
Lopez-Rodriguez, A ;
Steingrub, JS ;
Garber, GE ;
Helterbrand, JD ;
Ely, EW ;
Fisher, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709
[7]   Alveolar plasminogen activator inhibitor-1 predicts ARDS in aspiration pneumonitis [J].
El Solh, AA ;
Bhora, M ;
Pineda, L ;
Aquilina, A ;
Abbetessa, L ;
Berbary, E .
INTENSIVE CARE MEDICINE, 2006, 32 (01) :110-115
[8]   Plasminogen activator inhibitor-I potentiates LPS-induced neutrophil activation through a JNK-mediated pathway [J].
Kwak, Sang-Hyun ;
Wang, Xue-Qing ;
He, Qianbin ;
Fang, Wen-Feng ;
Mitra, Sanchayita ;
Bdeir, Khalil ;
Ploplis, Victoria A. ;
Xu, Zhi ;
Idell, Steven ;
Cines, Douglas ;
Abraham, Edward .
THROMBOSIS AND HAEMOSTASIS, 2006, 95 (05) :829-835
[9]   The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with αvβ3 integrins [J].
Kwak, SH ;
Mitra, S ;
Bdeir, K ;
Strassheim, D ;
Park, JS ;
Kim, JY ;
Idell, S ;
Cines, D ;
Abraham, E .
JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (04) :937-945
[10]   Randomized clinical trial of activated protein C for the treatment of acute lung injury [J].
Liu, Kathleen D. ;
Levitt, Joseph ;
Zhuo, Hanjing ;
Kallet, Richard H. ;
Brady, Sandra ;
Steingrub, Jay ;
Tidswell, Mark ;
Siegel, Mark D. ;
Soto, Graciela ;
Peterson, Michael W. ;
Chesnutt, Mark S. ;
Phillips, Charles ;
Weinacker, Ann ;
Thompson, B. Taylor ;
Eisner, Mark D. ;
Matthay, Michael A. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (06) :618-623
12