What can we learn from kidney organoids?

被引：13

作者：

Dorison, Aude ^{[1
,2
,3
]}

Forbes, Thomas A. ^{[1
,2
,4
]}

Little, Melissa H. ^{[1
,2
,3
]}

机构：

[1] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Paediat, Fac Med Dent & Hlth Sci, Parkville, Vic, Australia

[3] Univ Copenhagen, Novo Nordisk Fdn Ctr Stem Cell Med, Fac Hlth & Med Sci, Copenhagen, Denmark

[4] Royal Childrens Hosp, Dept Nephrol, Parkville, Vic, Australia

来源：

KIDNEY INTERNATIONAL | 2022年 / 102卷 / 05期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

PLURIPOTENT STEM-CELLS; IN-VITRO; DIRECTED DIFFERENTIATION; PROGENITOR POPULATION; DIVERGENT FEATURES; ENDOTHELIAL-CELLS; MOUSE MODEL; DISEASE; GENERATION; ORGANOGENESIS;

D O I：

10.1016/j.kint.2022.06.032

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The ability to generate 3-dimensional models of the developing human kidney via the directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed as a major advance in experimental nephrology. Although these provide an opportunity to interrogate human development, model-specific kidney diseases facilitate drug screening and even deliver bioengineered tissue; most of these prophetic end points remain to be realized. Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges. © 2022 International Society of Nephrology

引用

页码：1013 / 1029

页数：17

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