Evaluation of serum and tissue levels of alpha-tocopherol

被引：14

作者：

Brandt, RB

Kaugars, GE

Riley, WT

Bei, RA

Silverman, S

Lovas, JGL

Dezzutti, BP

Chan, W

机构：

[1] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PREVENT MED, RICHMOND, VA 23298 USA

[2] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT ORAL PATHOL, RICHMOND, VA 23298 USA

[3] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PSYCHIAT, RICHMOND, VA 23298 USA

[4] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PEDIAT NEPHROL, RICHMOND, VA 23298 USA

[5] UNIV CALIF SAN FRANCISCO, SCH DENT, DIV ORAL MED, SAN FRANCISCO, CA 94143 USA

[6] DALHOUSIE UNIV, FAC SCH DENT, HALIFAX, NS B3H 4HZ, CANADA

来源：

BIOCHEMICAL AND MOLECULAR MEDICINE | 1996年 / 57卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/bmme.1996.0009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to test the effect of supplementation of several antioxidants, including alpha-tocopherol, on the clinical reduction of premalignant oral lesions. Samples of oral mucosa and serum were taken from baseline to 9 months of supplementation from patients with premalignant oral lesions and analyzed for alpha-tocopherol by HPLC. Statistical increases in both serum and tissue alpha-tocopherol were found after supplementation. There was no statistical relationship between alpha-tocopherol and beta-carotene levels. (C) 1996 Academic Press, Inc.

引用

页码：64 / 66

页数：3

共 19 条

[1] SAFETY OF ORAL INTAKE OF VITAMIN-E [J].

BENDICH, A ;

MACHLIN, LJ .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 48 (03) :612-619

[2] REGRESSION OF ORAL LEUKOPLAKIA WITH ALPHA-TOCOPHEROL - A COMMUNITY CLINICAL ONCOLOGY PROGRAM CHEMOPREVENTION STUDY [J].

BENNER, SE ;

WINN, RJ ;

LIPPMAN, SM ;

POLAND, J ;

HANSEN, KS ;

LUNA, MA ;

HONG, WK .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (01) :44-47

[3] EVALUATION OF SERUM AND TISSUE-LEVELS OF BETA-CAROTENE [J].

BRANDT, R ;

KAUGARS, GE ;

RILEY, WT ;

DAO, QY ;

SILVERMAN, S ;

LOVAS, JGL ;

DEZZUTTI, BP .

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1994, 51 (01) :55-60

[4]

BRANDT RB, 1990, FASEB J, V4, pA1174

[5] SERUM RETINOL, BETA-CAROTENE, VITAMIN-E, AND SELENIUM AS RELATED TO SUBSEQUENT CANCER OF SPECIFIC SITES [J].

COMSTOCK, GW ;

BUSH, TL ;

HELZLSOUER, K .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 135 (02) :115-121

[6]

DOLL R, 1981, CAUSES CANCER, P1220

[7]

Garewal H, 1994, Eur J Cancer Prev, V3, P101, DOI 10.1097/00008469-199403000-00003

[8]

GAREWAL HS, 1995, ARCH OTOLARYNGOL, V121, P141

[9]

KAUGARS G, 1990, Oral Surgery Oral Medicine Oral Pathology, V70, P607

[10] A CLINICAL-TRIAL OF ANTIOXIDANT SUPPLEMENTS IN THE TREATMENT OF ORAL LEUKOPLAKIA [J].

KAUGARS, GE ;

SILVERMAN, S ;

LOVAS, JGL ;

BRANDT, RB ;

RILEY, WT ;

DAO, QE ;

SINGH, VN ;

GALLO, J .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1994, 78 (04) :462-468

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