Influence of climatic factors in the incidence of multiple sclerosis relapses in a Portuguese population

被引：21

作者：

Fonseca, A. C. ^{[1
]}

Costa, J. ^{[2
]}

Cordeiro, C. ^{[1
]}

Geraldes, R. ^{[1
]}

de Sa, J. ^{[1
]}

机构：

[1] Hosp Santa Maria, Serv Neurol, Dept Neurosci Neurol, P-1649035 Lisbon, Portugal

[2] Lisboa Fac Med, Lab Clin Pharmacol & Therapeut, IMM, Lisbon, Portugal

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2009年 / 16卷 / 04期

关键词：

atmospheric pressure; climatic factors; environmental factors; humidity; multiple sclerosis relapses; Portuguese population; seasons; temperature; OUTBREAKS;

D O I：

10.1111/j.1468-1331.2008.02528.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Environmental factors are thought to be important in multiple sclerosis (MS) pathophysiology. We aimed to evaluate if there was an association between MS relapses and some climatic factors in a Portuguese population. Four year retrospective study analyzing 414 MS relapses in 249 consecutive relapsing-remitting patients. Non-parametric statistics were used to compare the distribution of relapses across months and seasons. Spearman's coefficient was determined to evaluate the correlation between relapses frequency and maximum and minimum atmospheric temperatures, humidity and atmospheric pressure. The mean number of relapses was not significantly different between months or seasons. No correlation was found between relapse frequency and any climatic factor. Our series is one of the largest addressing the influence of specific climatic factors on MS relapses. The number of clinical MS relapses seems to be unrelated to climatic factors.

引用

页码：537 / 539

页数：3

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