Locus control regions and epigenetic chromatin modifiers

被引：62

作者：

Festenstein, R

Kioussis, D

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC,Clin Sci Ctr, Dept Med, London W12 0NN, England

[2] Natl Inst Med Res, Div Mol Immunol, London NW7 1AA, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(00)00060-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Locus control regions are defined as gene regulatory sequences that enable chromosomal position-independent gene expression in transgenic mice. Recent studies have shown the ability of such regions to overcome the highly repressive effect of heterochromatin and have identified both trans-acting and cis-acting factors that participate in gene silencing and activation mechanisms.

引用

页码：199 / 203

页数：5

共 59 条

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