Telomeres and telomerase: a dual role in hepatocarcinogenesis

被引：103

作者：

Satyanarayana, A ^{[1
]}

Manns, MP ^{[1
]}

Rudolph, KL ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany

来源：

HEPATOLOGY | 2004年 / 40卷 / 02期

关键词：

D O I：

10.1002/hep.20308

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Telomere shortening limits the proliferative capacity of primary human cells and restrains the regenerative capacity of organ systems during chronic diseases and aging. Telomere shortening apparently has a dual role in tumor development and progression. On the one hand, it induces chromosomal instability and the initiation of cancer; on the other hand, tumor progression requires stabilization of telomeres. The predominant mechanism of telomere stabilization in tumor cells is the activation of the telomere-synthesizing enzyme telomerase. The potential use of telomerase activators for the treatment of regenerative disorders will ultimately depend on their effects on tumorigenesis. This review focuses on the role of telomere shortening and telomerase in carcinogenesis with a special focus on hepatocellular carcinoma.

引用

页码：276 / 283

页数：8

共 87 条

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