Strategic Response to an Outbreak of Circulating Vaccine-Derived Poliovirus Type 2-Syria, 2017-2018

被引：22

作者：

Mbaeyi, Chukwuma ^{[1
]}

Wadood, Zubair Mufti ^{[2
]}

Moran, Thomas ^{[2
]}

Ather, Fazal ^{[3
]}

Stehling-Ariza, Tasha ^{[4
]}

Nikulin, Joanna ^{[2
]}

Al Safadi, Mohammad ^{[2
]}

Iber, Jane ^{[5
]}

Zomahoun, Laurel ^{[1
]}

Abourshaid, Nidal ^{[6
]}

Pang, Hong ^{[5
]}

Collins, Nikki ^{[5
]}

Asghar, Humayun ^{[2
]}

Butt, Obaid ul Islam ^{[2
]}

Burns, Cara C. ^{[5
]}

Ehrhardt, Derek ^{[1
]}

Sharaf, Magdi ^{[2
]}

机构：

[1] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA

[2] WHO, Polio Eradicat Dept, Geneva, Switzerland

[3] United Nations Childrens Fund, Middle East & North Africa Off, Amman, Jordan

[4] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA

[5] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA

[6] United Nations Childrens Fund, Syria Country Off, Damascus, Syria

来源：

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT | 2018年 / 67卷 / 24期

关键词：

PROGRESS; ERADICATION; WORLDWIDE;

D O I：

10.15585/mmwr.mm6724a5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

What is already known about this topic? Oral poliovirus vaccine (OPV) contains live attenuated viruses, which rarely revert to neurovirulence. These vaccine-derived polioviruses (VDPVs) tend to emerge in populations with low OPV coverage and are capable of causing paralysis. What is added by this report? In 2017, an outbreak of circulating VDPV type 2 (cVDPV2) occurred in Syria, causing 74 cases. Implementation of three rounds of monovalent OPV type 2 campaigns coupled with intensified surveillance interrupted the outbreak. What are the implications for public health practice? The outbreak in Syria underscores the risk for emergence of vaccine-derived polioviruses in settings of low OPV coverage. High-quality surveillance and targeted vaccination using monovalent OPV type 2 are effective in controlling cVDPV2 outbreaks. © 2018, Department of Health and Human Services. All Rights reserved.

引用

页码：690 / 694

页数：5

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