Predictors of oropharyngeal cancer survival in Europe

被引:23
作者
Anantharaman, D. [1 ,2 ]
Billot, A. [1 ]
Waterboer, T. [3 ]
Gheit, T. [1 ]
Abedi-Ardekani, B.
Lagiou, P. [4 ]
Lagiou, A. [5 ]
Ahrens, W. [6 ,7 ]
Holcatova, I. [8 ]
Merletti, F. [9 ]
Kjaerheim, K. [10 ]
Polesel, J. [11 ]
Simonato, L. [12 ]
Alemany, L. [13 ,14 ]
Cervigon, M. Mena [14 ]
Macfarlanene, T. V. [15 ]
Znaor, A.
Thomson, P. J. [16 ,17 ]
Robinson, M. [18 ]
Canova, C. [19 ]
Conway, D. I. [20 ,21 ]
Wright, S. [22 ]
Healy, C. M. [23 ]
Toner, M. E. [23 ]
Pawlita, M. [3 ]
Tommasino, M. [1 ]
Brennan, P. [1 ]
机构
[1] Int Agcy Res Canc, Lyon, France
[2] Canc Res Program, Rajiv Gandhi Ctr Biotechnol, Thiruvananthapuram, Kerala, India
[3] German Canc Res Ctr, Div Mol Diagnost Oncogen Infect, Heidelberg, Germany
[4] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg, Epidemiol & Med Stat, Athens, Greece
[5] Athens Technol Educ Inst, Sch Hlth Profess, Dept Publ Hlth & Community Hlth, Athens, Greece
[6] BIPS Inst Epidemiol & Prevent Res, Bremen, Germany
[7] Univ Bremen, Inst Stat, Bremen, Germany
[8] Charles Univ Prague, Inst Hyg & Epidemiol, Ist Fac Med, Prague, Czech Republic
[9] CeRMS & Univ Turin, Canc Epidemiol Unit, Turin, Italy
[10] Canc Registry Norway, Oslo, Norway
[11] Natl Canc Inst, Unit Epidemiol & Biostatist, IRCCS, Aviano, Italy
[12] Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy
[13] MInstitut Catala dOncologia, IDIBELL, CIBERESP, Lhospitalet De Llobregat, Spain
[14] Univ Aberdeen, Epidemiol Grp, Aberdeen, Scotland
[15] Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland
[16] Univ Queensland, Sch Dent, Herston, Qld, Australia
[17] Newcastle Univ, Ctr Oral Hlth Res, Newcastle Upon Tyne, Tyne & Wear, England
[18] Natl Heart & Lung Inst, Imperial Coll, Resp Epidemiol & Publ Hlth, London, England
[19] Natl Heart & Lung Inst, Imperial Coll, Resp Epidemiol & Publ Hlth, London, England
[20] Natl Heart & Lung Inst, Imperial Coll, Resp Epidemiol & Publ Hlth, London, England
[21] NHS Natl Serv Scotland, Informat Serv Div ISD, Edinburgh, Midlothian, Scotland
[22] Queen Elizabeth Univ Hosp, Dept Pathol, Glasgow, Lanark, Scotland
[23] Trin Coll Sch Dent Sci, Dublin, Ireland
关键词
Oropharynx cancer; HPV16; Survival; Tobacco; Body mass index; Gender; Head and neck cancer; AERODIGESTIVE TRACT CANCER; HUMAN-PAPILLOMAVIRUS; HEAD; RISK; ALCOHOL; INFECTIONS; THERAPY; TOBACCO; TRENDS; HPV;
D O I
10.1016/j.oraloncology.2018.04.016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: HPV16-positive oropharyngeal cancer (OPC) patients experience better outcomes compared to HPV16-negative patients. Currently, strategies for treatment de-escalation are based on HPV status, smoking history and disease stage. However, the appropriate cut-point for smoking and the role of other non-clinical factors in OPC survival remains uncertain. Materials and Methods: We examined factors associated with OPC outcome in 321 patients recruited in a large European multi-center study. Seropositivity for HPV16 E6 was used as a marker of HPV16 positive cancer. Hazard ratios (HR) and confidence intervals (CI) were estimated using Cox proportional models adjusted for potential confounders. Results: Overall 5-year survival following OPC diagnosis was 50%. HPV16-positive OPC cases were at significantly lower risk of death (aHR = 0.51, 95% CI: 0.32-0.80). A significant effect on OPC survival was apparent for female sex (aHR 0.50: 95% CI: 0.29-0.85) and being underweight at diagnosis (aHR: 2.41, 95% CI: 1.38-4.21). A 10 pack year smoking history was not associated with overall survival. Higher stage at diagnosis appeared as the only factor significantly associated with OPC recurrence (aHR: 4.88, 95% CI: 2.12-11.21). Conclusion: This study confirms that HPV16 status is an independent prognostic factor for OPC survival while female sex lowers risk of death and being underweight at diagnosis increases the risk of death. Smoking was not an independent predictor of OPC survival.
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收藏
页码:89 / 94
页数:6
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