Bio-based poly (γ-glutamic acid) hydrogels reinforced with bacterial cellulose nanofibers exhibiting superior mechanical properties and cytocompatibility

被引：34
作者：
Dou, Chunyan [1 ]
Li, Zheng [1 ]
Gong, Jixian [1 ]
Li, Qiujin [1 ]
Qiao, Changsheng [2 ]
Zhang, Jianfei [1 ]
机构：
[1] Tiangong Univ, Sch Text Sci & Engn, 399 Bingshui West Rd, Tianjin 300387, Peoples R China
[2] Tianjin Univ Sci & Technol, Key Lab Ind Microbiol, Minist Educ, Tianjin 300457, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 170卷
关键词：
Poly (gamma-glutamic acid); Bacterial cellulose nanofibers; Hydrogel; Mechanical properties; Cytocompatibility;
D O I：
10.1016/j.ijbiomac.2020.12.148
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural polymer hydrogels are expected to be promising biomaterial because of its excellent biocompatibility and biodegradability, but they are soft and easily broken. Herein, the poly (gamma-glutamic acid) (gamma-PGA)/bacterial cellulose (BC) composite hydrogels with excellent mechanical properties were constructed by introducing bacterial cellulose. The gamma-PGA/BC composite hydrogels were obtained by the covalent cross-linking of gamma-PGA in the BC nanofibers suspensions. The gamma-PGA/BC composite hydrogels exhibited excellent strength and toughness due to the more effective energy dissipation of hydrogen bonds network among BC nanofibers and gamma-PGA hydrogel matrix and BC also acts as an enhancer. The compressive fracture strength and toughness of the gamma-PGA/BC composite hydrogels could reach up to 5.72 MPa and 0.42 MJ/m(3) respectively. Additionally, the tensile strength of gamma-PGA/BC composite hydrogels were improved 8.16 times compared with gamma-PGA single network hydrogels. More significantly, BC could disperse evenly in the gamma-PGA hydrogels because of the hydrophilic nature of gamma-PGA and BC nanofillers, which led to good interface compatibility. The result of cytotoxicity tests indicated that gamma-PGA/BC composite hydrogels present excellent cytocompatibility, which suggested that the gamma-PGA/BC composite hydrogels could serve as promising materials for many biomaterial related applications. (C) 2020 Elsevier B.V. All rights reserved.
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页码：354 / 365
页数：12
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