Bio-based poly (γ-glutamic acid) hydrogels reinforced with bacterial cellulose nanofibers exhibiting superior mechanical properties and cytocompatibility

被引：34

作者：

Dou, Chunyan ^{[1
]}

Li, Zheng ^{[1
]}

Gong, Jixian ^{[1
]}

Li, Qiujin ^{[1
]}

Qiao, Changsheng ^{[2
]}

Zhang, Jianfei ^{[1
]}

机构：

[1] Tiangong Univ, Sch Text Sci & Engn, 399 Bingshui West Rd, Tianjin 300387, Peoples R China

[2] Tianjin Univ Sci & Technol, Key Lab Ind Microbiol, Minist Educ, Tianjin 300457, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 170卷

关键词：

Poly (gamma-glutamic acid); Bacterial cellulose nanofibers; Hydrogel; Mechanical properties; Cytocompatibility;

D O I：

10.1016/j.ijbiomac.2020.12.148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural polymer hydrogels are expected to be promising biomaterial because of its excellent biocompatibility and biodegradability, but they are soft and easily broken. Herein, the poly (gamma-glutamic acid) (gamma-PGA)/bacterial cellulose (BC) composite hydrogels with excellent mechanical properties were constructed by introducing bacterial cellulose. The gamma-PGA/BC composite hydrogels were obtained by the covalent cross-linking of gamma-PGA in the BC nanofibers suspensions. The gamma-PGA/BC composite hydrogels exhibited excellent strength and toughness due to the more effective energy dissipation of hydrogen bonds network among BC nanofibers and gamma-PGA hydrogel matrix and BC also acts as an enhancer. The compressive fracture strength and toughness of the gamma-PGA/BC composite hydrogels could reach up to 5.72 MPa and 0.42 MJ/m(3) respectively. Additionally, the tensile strength of gamma-PGA/BC composite hydrogels were improved 8.16 times compared with gamma-PGA single network hydrogels. More significantly, BC could disperse evenly in the gamma-PGA hydrogels because of the hydrophilic nature of gamma-PGA and BC nanofillers, which led to good interface compatibility. The result of cytotoxicity tests indicated that gamma-PGA/BC composite hydrogels present excellent cytocompatibility, which suggested that the gamma-PGA/BC composite hydrogels could serve as promising materials for many biomaterial related applications. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：354 / 365

页数：12

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