Spontaneous growth of 83 Chilean girls with Turner's syndrome

Background: Short stature is the main feature of patients with Turner's syndrome. There is limited information regarding the spontaneous growth of these Patients in Chile. Aim: To develop a specific growth chart for Chilean patients with Turner's syndrome. Material and methods: We retrospectively analyzed 668 height measurements from 85 Chilean girls, born after 1968, with 45XO karyotype (minimum 15%), and without all Y chromosome fragment. Patients with hormonal therapy, such as growth hormone or estrogen, except thyroid hormone replacement, were excluded. Results: The karyotypes were 60% 45XO, 25% 45XO, 46XY, and 15% other complex mosaics. The birth length was 468 +/- 2.1 cm. The final height of our patients was 138,20 +/- 7,0 cm. Conclusions: The final height achieved by our patients, is similar to Argentinian and Japanese Patients, but is below the mean stature reported for Scandinavian and Northamerican patients who achieve a mean adult height of approximately 147;and 142 cm respectively. The birth length is also lower than that reported in those studies.