Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

被引：9
作者：
Liu, Yi-Fu [1 ]
Fu, Sheng-Qiang [1 ]
Yan, Yu-Chang [1 ]
Gong, Bin-Bin [1 ]
Xie, Wen-Jie [1 ]
Yang, Xiao-Rong [1 ]
Sun, Ting [1 ]
Ma, Ming [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 1, Dept Urol, Nanchang 330000, Jiangxi, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2021年 / 15卷
关键词：
gonadotropin-releasing hormone; prostate cancer; degarelix; relugolix; ANDROGEN-DEPRIVATION THERAPY; ANTIANDROGEN FLARE PROTECTION; URINARY-TRACT SYMPTOMS; III EXTENSION TRIAL; OF-LIFE IMPROVEMENT; OPEN-LABEL; GNRH ANTAGONIST; PHASE-II; JAPANESE PATIENTS; 1-ARM CROSSOVER;
D O I：
10.2147/DDDT.S291369
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Gonadotropin-releasing hormone (GnRH) receptor agonists are still the most commonly used androgen deprivation treatment (ADT) drugs for prostate cancer in clinical practice. Currently, the GnRH receptor antagonists used for endocrine therapy for prostate cancer primarily include degarelix and relugolix (TAK-385). The former is administered by subcutaneous injection, while the latter is an oral drug. Compared to GnRH agonists, GnRH antagonists reduce serum testosterone levels more rapidly without an initial testosterone surge or subsequent microsurges. This review focuses on the mechanism of action of GnRH antagonists and agonists, the developmental history of GnRH antagonists, and emerging data from clinical studies of the two antagonists used as endocrine therapy for prostate cancer.
引用
收藏
页码：639 / 649
页数：11
相关论文
共 50 条
  • [21] Gonadotropin-releasing hormone antagonists versus standard androgen suppression therapy for advanced prostate cancer A systematic review with meta-analysis
    Kunath, Frank
    Borgmann, Hendrik
    Bluemle, Anette
    Keck, Bastian
    Wullich, Bernd
    Schmucker, Christine
    Sikic, Danijel
    Roelle, Catharina
    Schmidt, Stefanie
    Wahba, Amr
    Meerpohl, Joerg J.
    BMJ OPEN, 2015, 5 (11):
  • [22] Degarelix versus luteinizing hormone-releasing hormone agonists for the treatment of prostate cancer
    Clinton, Timothy N.
    Woldu, Solomon L.
    Raj, Ganesh V.
    EXPERT OPINION ON PHARMACOTHERAPY, 2017, 18 (08) : 825 - 832
  • [23] Gonadotropin-releasing hormone agonists in prostate cancer: A comparative review of efficacy and safety
    Raja, T.
    Sud, Rahul
    Addla, Sanjai
    Sarkar, Kalyan K.
    Sridhar, P. S.
    Talreja, Vikas
    Jain, Minish
    Patil, Ketaki
    INDIAN JOURNAL OF CANCER, 2022, 59 : S142 - S159
  • [24] Gonadotropin-releasing Hormone Agonists and Acute Kidney Injury in Patients with Prostate Cancer
    Gandaglia, Giorgio
    Sun, Maxine
    Huc, Jim C.
    Novara, Giacomo
    Choueiri, Toni K.
    Nguyen, Paul L.
    Schiffmann, Jonas
    Graefen, Markus
    Shariat, Shahrokh F.
    Abdollah, Firas
    Briganti, Alberto
    Montorsi, Francesco
    Quoc-Dien Trinh
    Karakiewicz, Pierre I.
    EUROPEAN UROLOGY, 2014, 66 (06) : 1125 - 1132
  • [25] Gonadotropin-releasing hormone receptors in prostate tissue
    Bono, AV
    Salvadore, M
    Celato, N
    ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, 2002, 24 (04): : 221 - 227
  • [26] Gonadoliberin (Gonadotropin-Releasing Hormone), Its Agonists and Antagonists
    Holicka, Martina
    Vyslouzil, Jakub
    Kubova, Katerina
    Muselik, Jan
    Vetchy, David
    CHEMICKE LISTY, 2021, 115 (10): : 516 - 523
  • [27] A potential new use for gonadotropin-releasing hormone antagonists
    Aust, TR
    Sklavounos, J
    Kingsland, CR
    Gazvani, R
    FERTILITY AND STERILITY, 2003, 80 (03) : 641 - 642
  • [28] Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro
    Stephenson, Rachel
    Varamini, Pegah
    Butcher, Neville
    Minchin, Rodney
    Toth, Istvan
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2014, 10 (08) : 1799 - 1808
  • [29] Cardiovascular Risk in Prostate Cancer Patients Using Luteinizing Hormone-Releasing Hormone Agonists or a Gonadotropin-Releasing Hormone Antagonist
    Crawford, E. David
    Hafron, Jason M.
    Debruyne, Frans
    Wallis, Christopher
    Chang, Steven
    Garnick, Marc B.
    JOURNAL OF UROLOGY, 2024, 211 (01) : 63 - 70
  • [30] Biochemistry, molecular biology and cell biology of gonadotropin-releasing hormone antagonists
    Tan, Orkun
    Bukulmez, Orhan
    CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2011, 23 (04) : 238 - 244
12345