Effect of chitosan molecular weight on zein-chitosan nanocomplexes: Formation, characterization, and the delivery of quercetagetin

被引：60
作者：
Chen, Shuai [1 ]
Ma, Xihan [1 ]
Han, Yahong [2 ]
Wei, Yang [1 ]
Guo, Qing [1 ]
Yang, Shufang [1 ]
Zhang, Yanhui [1 ]
Liao, Wenyan [1 ]
Gao, Yanxiang [1 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
[2] Huazhong Agr Univ, Coll Engn, Wuhan 430070, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 164卷
关键词：
Chitosan; Zein; Nanocomplexes; Molecular weight; Quercetagetin; STRUCTURAL-CHARACTERIZATION; PHYSICOCHEMICAL PROPERTIES; COMPLEX NANOPARTICLES; ENCAPSULATION; FABRICATION; RESVERATROL; ANTIOXIDANT; SYSTEMS; DISPERSIONS; TEMPERATURE;
D O I：
10.1016/j.ijbiomac.2020.07.245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The impacts of chitosan with different molecular weight on the formation mechanism, structural characteristics and encapsulating properties of the zein-chitosan nanocomplexes were investigated. The results of dynamic light scattering showed that the mean size of nanocomplexes was increased and became more highly positive charge as the molecular weight of chitosan was increased. Circular dichroism indicated that the secondary structure of zein changed after its combination of chitosan. XRD confirmed that quercetagetin was successfully encapsulated into the nanocomplexes, and FTIR revealed that hydrogen bonding and hydrophobic interaction were the main forces acting among the zein, quercetagetin, and chitosan molecules. The optimized zein-Que-LCH (low molecular weight chitosan) nanocomplexes were relatively small (309 nm), positively charged (+42.5 mV), and had a high entrapment efficiency (94.9%). Moreover, encapsulation of quercetagetin within the nanocomplexes extended its half-life by 3.84- and 2.98- folds during the photo- and thermal-degradation measurements, and effectively modulated its release under simulated gastrointestinal conditions. (C) 2020 Elsevier B.V. All rights reserved.
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收藏
页码：2215 / 2223
页数：9
相关论文
共 52 条
[1]   Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin [J].
Baek, Sohee ;
Kang, Nam Joo ;
Popowicz, Grzegorz M. ;
Arciniega, Marcelino ;
Jung, Sung Keun ;
Byun, Sanguine ;
Song, Nu Ry ;
Heo, Yong-Seok ;
Kim, Bo Yeon ;
Lee, Hyong Joo ;
Holak, Tad A. ;
Augustin, Martin ;
Bode, Ann M. ;
Huber, Robert ;
Dong, Zigang ;
Lee, Ki Won .
JOURNAL OF MOLECULAR BIOLOGY, 2013, 425 (02) :411-423
[2]   Effect of glycerol and corn oil on physicochemical properties of polysaccharide films - A comparative study [J].
Cerqueira, Miguel A. ;
Souza, Bartolomeu W. S. ;
Teixeira, Jose A. ;
Vicente, Antonio A. .
FOOD HYDROCOLLOIDS, 2012, 27 (01) :175-184
[3]   Zein/caseinate/pectin complex nanoparticles: Formation and characterization [J].
Chang, Chao ;
Wang, Taoran ;
Hu, Qiaobin ;
Luo, Yangchao .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 104 :117-124
[4]   Synthesis and self-assembly of octenyl succinic anhydride modified short glucan chains based amphiphilic biopolymer: Micelles, ultrasmall micelles, vesicles, and lutein encapsulation/release [J].
Chang, Ranran ;
Yang, Jie ;
Ge, Shengju ;
Zhao, Mei ;
Liang, Caifeng ;
Xiong, Liu ;
Sun, Qingjie .
FOOD HYDROCOLLOIDS, 2017, 67 :14-26
[5]   Co-delivery of curcumin and piperine in zein-carrageenan core-shell nanoparticles: Formation, structure, stability and in vitro gastrointestinal digestion [J].
Chen, Shuai ;
Li, Qike ;
McClements, David Julian ;
Han, Yahong ;
Dai, Lei ;
Mao, Like ;
Gao, Yanxiang .
FOOD HYDROCOLLOIDS, 2020, 99
[6]   Fabrication and Characterization of Layer-by-Layer Composite Nanoparticles Based on Zein and Hyaluronic Acid for Codelivery of Curcumin and Quercetagetin [J].
Chen, Shuai ;
Han, Yahong ;
Huang, Jingyang ;
Dai, Lei ;
Du, Juan ;
McClements, David Julian ;
Mao, Like ;
Liu, Jinfang ;
Gao, Yanxiang .
ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (18) :16922-16933
[7]   Effect of molecular weight of hyaluronan on zein-based nanoparticles: Fabrication, structural characterization and delivery of curcumin [J].
Chen, Shuai ;
Han, Yahong ;
Sun, Cuixia ;
Dai, Lei ;
Yang, Shufang ;
Wei, Yang ;
Mao, Like ;
Yuan, Fang ;
Gao, Yanxiang .
CARBOHYDRATE POLYMERS, 2018, 201 :599-607
[8]   Dry fractionation of surface abrasion for polyphenol-enriched buckwheat protein combined with hydrothermal treatment [J].
Chen, Xiao-Wei ;
Luo, Dan-Yang ;
Chen, Ya-Jun ;
Wang, Jin-Mei ;
Guo, Jian ;
Yang, Xiao-Quan .
FOOD CHEMISTRY, 2019, 285 :414-422
[9]   Stabilizing zein nanoparticle dispersions with ι-carrageenan [J].
Cheng, Christopher J. ;
Jones, Owen G. .
FOOD HYDROCOLLOIDS, 2017, 69 :28-35
[10]   Development of protein-polysaccharide-surfactant ternary complex particles as delivery vehicles for curcumin [J].
Dai, Lei ;
Wei, Yang ;
Sun, Cuixia ;
Mao, Like ;
McClements, David Julian ;
Gao, Yanxiang .
FOOD HYDROCOLLOIDS, 2018, 85 :75-85
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