Phase behavior of beta hydroxy-acids with Laureth 4

被引：3

作者：

Friberg, Stig E.

Al Bawab, Abeer ^{[1
]}

机构：

[1] Univ Virginia, Chem Dept, Charlottesville, VA 22911 USA

[2] Univ Jordan, Fac Sci, Chem Dept, Amman 11942, Jordan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2006年 / 95卷 / 08期

关键词：

beta hydroxy-acids; liquid crystals; emulsions; solubilization; skin lotions; phase equilibria;

D O I：

10.1002/jps.20554

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The colloidal structures of beta carboxylic acid topical vesicle formulations were determined and the changes during evaporation after applications were estimated from phase diagrams. The results showed significant difference during evaporation between salicylic acid on one hand and three water soluble acids; malic, tartaric, and citric acid, on the other. The water soluble acids showed an increase in the acid concentration in the aqueous solution to levels that must be considered harmful, while salicylic acid showed no increase in concentration in the individual phases even after 99% evaporation of water. (c) 2006 Wiley-Liss, Inc.

引用

页码：1834 / 1840

页数：7

共 19 条

[1]

Al Bawab A, 2004, Int J Cosmet Sci, V26, P273, DOI 10.1111/j.1467-2494.2004.00227.x

[2] Phase equilibria in the systems of acetic and glycolic acid with water and Laureth 4 [J].