Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

被引：48

作者：

Eggimann, Gabriela A. ^{[1
]}

Blattes, Emilyne ^{[1
]}

Buschor, Stefanie ^{[1
]}

Biswas, Rasomoy ^{[1
]}

Kammer, Stephan M. ^{[1
]}

Darbre, Tamis ^{[1
]}

Reymond, Jean-Louis ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 55期

基金：

瑞士国家科学基金会;

关键词：

MEMBRANE-PERMEABLE PEPTIDES; ARGININE-RICH PEPTIDES; MOLECULAR TRANSPORTERS; CYCLIC-PEPTIDES; IN-VITRO; DELIVERY; TAT; PVEC; RESISTANCE; PACLITAXEL;

D O I：

10.1039/c4cc02780a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

引用

页码：7254 / 7257

页数：4

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