A New Twist on Brown Fat Metabolism

被引：6
作者：
Wallberg-Henriksson, Harriet [1 ,2 ]
Zierath, Juleen R. [1 ,2 ]
机构：
[1] Karolinska Inst, Sect Integrat Physiol, Dept Mol Med & Surg, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Sect Integrat Physiol, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
来源：
CELL | 2009年 / 137卷 / 01期
关键词：
DELTA;
D O I：
10.1016/j.cell.2009.03.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcriptional coactivator PGC-1 alpha promotes mitochondrial biogenesis and thermogenic programs in brown adipose tissue. Pan et al. (2009) identify the transcription factor twist-1 as a negative feedback regulator of PGC-1 alpha.
引用
收藏
页码：22 / 24
页数：4
相关论文
共 9 条
  • [1] Brown adipose tissue: Function and physiological significance
    Cannon, B
    Nedergaard, J
    [J]. PHYSIOLOGICAL REVIEWS, 2004, 84 (01) : 277 - 359
  • [2] Obesity and polymorphisms in genes regulating human adipose tissue
    Dahlman, I.
    Arner, P.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2007, 31 (11) : 1629 - 1641
  • [3] Role of AMP kinase and PPARδ in the regulation of lipid and glucose metabolism in human skeletal muscle
    Kraemer, David Kitz
    Al-Khalili, Lubna
    Guigas, Bruno
    Leng, Ying
    Garcia-Roves, Pablo M.
    Krook, Anna
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (27) : 19313 - 19320
  • [4] Unexpected evidence for active brown adipose tissue in adult humans
    Nedergaard, Jan
    Bengtsson, Tore
    Cannon, Barbara
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (02): : E444 - E452
  • [5] Pantke O A, 1975, Birth Defects Orig Artic Ser, V11, P190
  • [6] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    Puigserver, P
    Wu, ZD
    Park, CW
    Graves, R
    Wright, M
    Spiegelman, BM
    [J]. CELL, 1998, 92 (06) : 829 - 839
  • [7] A New Twist on Twist Modulation of the NF-κB Pathway
    Sosic, Drazen
    Olson, Eric N.
    [J]. CELL CYCLE, 2003, 2 (02) : 76 - 78
  • [8] THE TWIST GENE - ISOLATION OF A DROSOPHILA ZYGOTIC GENE NECESSARY FOR THE ESTABLISHMENT OF DORSOVENTRAL PATTERN
    THISSE, B
    ELMESSAL, M
    PERRINSCHMITT, F
    [J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (08) : 3439 - 3453
  • [9] Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    Wang, YX
    Lee, CH
    Tiep, S
    Yu, RT
    Ham, JY
    Kang, HJ
    Evans, RM
    [J]. CELL, 2003, 113 (02) : 159 - 170
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