Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review

被引：31

作者：

Lukasik, Jan ^{[1
]}

Patro-Golab, Bernadeta ^{[1
]}

Horvath, Andrea ^{[1
]}

Baron, Ruth ^{[2
]}

Szajewska, Hania ^{[1
]}

Besseling-van der Vaart, Isolde ^{[2
]}

Gieruszczak-Bialek, Dorota ^{[1
]}

Kolodziej, Maciej ^{[1
]}

Piescik-Lech, Malgorzata ^{[1
]}

Seidell, Jaap ^{[2
]}

Skorka, Agata ^{[1
]}

Taye, Meron ^{[2
]}

Ujcic, Joanne ^{[2
]}

Verhoeff, Arnoud ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Paediat, Zwirki & Wigury 63A, PL-02091 Warsaw, Poland

[2] Sarphati Amsterdam, Amsterdam, Netherlands

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2019年 / 49卷 / 09期

关键词：

Autism; Antibiotics; Early life; Risk factors; DISABILITIES MONITORING NETWORK; NEONATAL RISK-FACTORS; AGED; 8; YEARS; UNITED-STATES; RECALL BIAS; 11; SITES; CHILDREN; INFECTION; PREGNANCY; ASSOCIATION;

D O I：

10.1007/s10803-019-04093-y

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case-control study; in three other case-control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case-control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development.

引用

页码：3866 / 3876

页数：11

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