Stem cell plasticity and tumour formation

被引：29

作者：

Alison, Malcolm R.

Lovell, Matthew J.

Direkze, Natalie C.

Wright, Nicholas A.

Poulsom, Richard

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Diabet & Metab Med, Inst Cell & Mol Sci, London E1 2AT, England

[2] Canc Res UK, Histopathol Unit, London WC2A 3PX, England

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 09期

关键词：

haematopoietic stem cells; transdifferentiation; cell fusion; neovascularisation; endothelial progenitor cells; mesenchymal stem cells; myofibroblasts; desmoplasia; tumour stroma;

D O I：

10.1016/j.ejca.2006.01.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stem cell plasticity refers to the ability of certain stem cells to switch lineage determination and generate unexpected cell types. This review applies largely to bone mar-row cells (BMCs), which appear to contribute positively to the regeneration of several damaged non-haematopoietic tissues. This beneficial effect on regeneration may be a direct result of BMCs giving rise to organ parenchymal cells. Alternatively, it could be due to BMCs fusing with existing parenchymal cells, or providing paracrine growth factor support, or contributing to neovascularisation. In the context of oncology, BMC derivation of the tumour stroma and vasculature has profound biological and therapeutic implications, and there are several examples of carcinomas seemingly being derived from BMCs. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1247 / 1256

页数：10

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