A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone

被引：41

作者：

Li, Yanlin ^{[1
,2
]}

Han, Rui ^{[1
]}

Geng, Chengkui ^{[3
]}

Wang, Yongnian ^{[1
]}

Wei, Lei ^{[2
]}

机构：

[1] Kunming Med Coll, Affiliated Hosp 1, Dept Orthopaed, Kunming 650032, Peoples R China

[2] Brown Alpert Med Sch, Dept Orthopaed, Providence, RI 02903 USA

[3] First Peoples Hosp Kunming City, Dept Orthopaed, Kunming 650011, Peoples R China

来源：

INTERNATIONAL ORTHOPAEDICS | 2009年 / 33卷 / 02期

关键词：

STEROID-INDUCED OSTEONECROSIS; MESENCHYMAL STEM-CELLS; INDUCED HYPERTHERMIA; CANCELLOUS BONE; STROMAL CELLS; GROWTH; FAILURE; RABBITS; TUMORS; GRAFT;

D O I：

10.1007/s00264-008-0672-2

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The objective of this research was to induce a new animal model of osteonecrosis of the femoral head (ONFH) by microwave heating and then repair with tissue engineered bone. The bilateral femoral heads of 84 rabbits were heated by microwave at various temperatures. Tissue engineered bone was used to repair the osteonecrosis of femoral heads induced by microwave heating. The roentgenographic and histological examinations were used to evaluate the results. The femoral heads heated at 55A degrees C for ten minutes showed low density and cystic changes in X-ray photographs, osteonecrosis and repair occurred simultaneously in histology at four and eight weeks, and 69% femoral heads collapsed at 12 weeks. The ability of tissue engineered bone to repair the osteonecrosis was close to that of cancellous bone autograft. The new animal model of ONFH could be induced by microwave heating, and the tissue engineering technique will provide an effective treatment.

引用

页码：573 / 580

页数：8

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