Copper(I)-catalyzed asymmetric hydrosilylations of imines at ambient temperatures

被引：159

作者：

Lipshutz, BH ^{[1
]}

Shimizu, H ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 17期

关键词：

copper; hydrides; hydrosilylation; P ligands; reduction;

D O I：

10.1002/anie.200353294

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Are you looking for an operationally simple means of preparing enantio-enriched benzylic-like centers bearing nitrogen? Consider this new and convenient alternative to asymmetric hydrogenation: CuH when ligated by an enantio-pure SEGPHOS ligand can catalytically reduce aryl ketimines at room temperature in high yields and even higher ee values (see scheme; TMDS=tetramethyldisiloxane).

引用

页码：2228 / 2230

页数：3

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