Disease progression modeling of Alzheimer's disease according to education level

被引：21

作者：

Kim, Ko Woon ^{[1
,2
,3
,4
]}

Woo, Sook Young ^{[5
]}

Kim, Seonwoo ^{[5
]}

Jang, Hyemin ^{[1
,6
]}

Kim, Yeshin ^{[1
,7
]}

Cho, Soo Hyun ^{[1
,8
]}

Kim, Si Eun ^{[1
,9
]}

Kim, Seung Joo ^{[1
,10
,11
]}

Shin, Byoung-Soo ^{[2
,3
,4
]}

Kim, Hee Jin ^{[1
,6
]}

Na, Duk L. ^{[1
,6
,12
,13
]}

Seo, Sang Won ^{[1
,12
,13
,14
]}

机构：

[1] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, 81 Irwon Dong, Seoul 06351, South Korea

[2] Jeonbuk Natl Univ Hosp, Sch Med, Dept Neurol, Jeonju, South Korea

[3] Jeonbuk Natl Univ, Res Inst Clin Med, Jeonju, South Korea

[4] Jeonbuk Natl Univ Hosp, Biomed Inst, Jeonju, South Korea

[5] Samsung Med Ctr, Stat & Data Ctr, Seoul, South Korea

[6] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[7] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Neurol, Coll Med, Chunchon, South Korea

[8] Chonnam Natl Univ, Dept Neurol, Med Sch & Hosp, Gwangju, South Korea

[9] Inje Univ, Haeundae Paik Hosp, Dept Neurol, Coll Med, Busan, South Korea

[10] Gyeongsang Natl Univ, Dept Neurol, Sch Med, Chang Won, South Korea

[11] Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea

[12] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul, South Korea

[13] Samsung Med Ctr, Samsung Alzheimer Res Ctr, Seoul, South Korea

[14] Sungkyunkwan Univ, Dept Intelligent Precis Healthcare Convergence, Sch Med, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

MILD COGNITIVE IMPAIRMENT; DECLINE; DEMENTIA; DIAGNOSIS; SCALE;

D O I：

10.1038/s41598-020-73911-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To develop a disease progression model of Alzheimer's disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to the end stage of AD dementia (ADD) and to investigate the effect of education level on the whole disease spectrum, we enrolled 565 patients who were followed up more than three times and had a clinical dementia rating sum of boxes (CDR-SB). Three cohorts, SCI (n=85), amnestic mild cognitive impairment (AMCI, n=240), and ADD (n=240), were overlapped in two consecutive cohorts (SCI and AMCI, AMCI and ADD) to construct a model of disease course, and a model with multiple single-cohorts was estimated using a mixed-effect model. To examine the effect of education level on disease progression, the disease progression model was developed with data from lower (<= 12) and higher (>12) education groups. Disease progression takes 274.3 months (22.9 years) to advance from 0 to 18 points using the CDR-SB. Based on our predictive equation, it takes 116.5 months to progress from SCI to AMCI and 56.2 months to progress from AMCI to ADD. The rate of CDR-SB progression was different according to education level. The lower-education group showed faster CDR-SB progression from SCI to AMCI compared to the higher-education group, and this trend disappeared from AMCI to ADD. In the present study, we developed a disease progression model of AD spectrum from SCI to the end stage of ADD. Our disease modeling provides us with more understanding of the effect of education on cognitive trajectories.

引用

页数：9

共 36 条

[1]

Albert M., 2018, BRAIN, DOI DOI 10.1093/brain/awx365

[2] Age-related cognitive decline during normal aging:: The complex effect of education [J].