Co-exposure of lipopolysaccharide and pseudomonas aeruginosa exotoxin A-induced multiple organ injury in rats

被引：7

作者：

Chiu, Chien-Chao ^{[1
]}

Huang, Yen-Te ^{[2
]}

Chuang, Hsiao-Li ^{[1
]}

Chen, Hans Hsien-Chuan ^{[3
]}

Chung, Tung-Ching ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan

[2] Anim Ctr, Natl Appl Res Labs, Natl Lab, Taipei, Taiwan

[3] Yushu BiotechPath Consulting Ltd, Taipei, Taiwan

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2009年 / 31卷 / 01期

关键词：

Cytokines; lipopolysaccharide; multiple organ injury; pseudomonas aeruginosa exotoxin A; GADOLINIUM CHLORIDE; KUPFFER CELLS; LIVER-INJURY; B-1; HEPATOTOXICITY; APOPTOSIS; MICE; POSTTREATMENT; ENDOTOXIN; BACTERIAL; RECEPTOR;

D O I：

10.1080/08923970802357724

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudomonas aeruginosa Exotoxin A (PEA) induces hepatotoxicity in experimental animals. Lipopolysaccharide (LPS) interacts synergistically with xenotoxics to induce severe organ injury. We examined the combination of non-injurious doses of LPS and sub-hepatotoxic PEA in the induction of multiple organ injury (MOI). Rats treated with 20 or 40 g/kg LPS plus 10 g/kg PEA developed severe liver, kidney, and lung injury; elevation of TNF-, IFN-, and IL-2; and high mortality. Depletion of Kupffer cells or T-cells by pretreatment with Gadolinium Chloride or FK506, respectively, attenuated MOI. Thus LPS + PEA acted synergistically on Kupffer and T-cells to induce proinflammatory cytokines contributing to MOI.

引用

页码：75 / 82

页数：8

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